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Oxidative Changes Induced by a Mineral Deficient Diet¹

Laboratory of Physiological Chemistry, Yale University, School of Medicine, New Haven, Connecticut

The respiratory quotients of rats receiving a diet deficient in inorganic salts were almost identical with those of control animals during the first month on the diets. During the second and third months, however, the respiratory quotients of the low-salt animals were significantly lower than those of their controls. The mineral deficiency apparently resulted in the oxidation of relatively larger proportions of fat and smaller proportions of carbohydrates, while it was practically without effect on the protein metabolized.

In spite of the differences in the total heat production there were no significant differences between the specific dynamic effects of the diets compared, as these effects are generally defined. This is explained by the fact that the increases in the total metabolism caused by the mineral deficiency can be fully accounted for by similar increases in the basal metabolism.

A preliminary report was presented before the American Institute of Nutrition, third meeting, Washington, March, 1936.

² Block Fellow in Physiological Chemistry, Yale University, 1934–1935.

³ Now at Wayne University, College of Medicine, Detroit.

Manuscript received 13 May 1938.