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The Production of Manganese Rickets in Rats

Department of Biochemistry, School of Hygiene and Public Health, Johns Hopkins University; Harriet Lane Home of the Johns Hopkins Hospital, and Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland

1. ‘Manganese rickets’ has been produced in rats by the substitution of an equimolar amount of manganese carbonate (2.9%) for 2.5% of calcium carbonate in a high calcium-low phosphorus rachitogenic diet, and also by the addition of 2.9% of manganese carbonate to a stock diet of optimal calcium and phosphorus content.

2. A soluble manganese salt, manganous chloride, was rachitogenic, but the more difficulty soluble manganese dioxide was not.

3. Vitamin D was effective in curing ‘manganese rickets’ when added to a diet optimal in calcium and phosphorus, but only slightly effective when added to a diet low in both calcium and phosphorus.

² Aided by a grant from Mead Johnson and Company, Evansville, Indiana.

Manuscript received 31 May 1938.