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Journal of Nutrition Vol. 16 No. 3 September 1938, pp. 285-290
Copyright © 1938 by American Society for Nutrition
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Fatty Livers in Vitamin B6 Deficient Rats

Nellie Halliday1

Department of Biochemistry and Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York

A study was made of the lipid content of livers of rats deficient invitamin B6, as compared with normal animals and with deficient animals which had been given choline.

The results show a significantly heavier liver containing a higher percentage of total fatty acids in the deficient animals. The addition of choline remedied the condition to a large extent, but even massive doses failed to bring the liver weight and total fatty acid content quite to normal.

Storage of the lipid extracts for a period of about 3 months resulted in losses in both total fatty acids and phospholipid fatty acids, no change in total cholesterol values and a definite drop in all iodine numbers.


1 Present address New England Deaconess Hospital, Boston, Massachusetts.

Manuscript received 28 February 1938.


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R. M. WILDER, H. C. BROWNE, and H. R. BUTT
DISEASES OF METABOLISM AND NUTRITION: REVIEW OF CERTAIN RECENT CONTRIBUTIONS
Arch Intern Med, February 1, 1940; 65(2): 390 - 460.
[Abstract] [PDF]




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