American Society for Nutrition
J. Nutr. First published December 23, 2009; doi:10.3945/jn.109.114496
 Journal of Nutrition, doi:10.3945/jn.109.114496
Vol. 140, No. 2, 407-410, February 2010
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© 2010 American Society for Nutrition

Symposium—The Development and Legacy of the INCAP Oriente Studies 1969–2009

Probability, Plausibility, and Adequacy Evaluations of the Oriente Study Demonstrate That Supplementation Improved Child Growth1,2

Jean-Pierre Habicht3,* and Reynaldo Martorell4

3 Division of Nutrition Sciences, Cornell University, Ithaca, NY 14853; 4 Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30083

This article presents evidence that the high-nutrient supplement in the Oriente study (Atole) improved child growth. The evidence is presented at 4 levels. There was a causal effect of the intervention on child length, as assessed by probability analyses of the randomized, controlled trial (P < 0.05). The plausibility analyses, which included an examination of wasting, showed that the nutritional impact was due to the Atole, especially in those who were <3 y old and who suffered from diarrhea. The adequacy analyses revealed excellent biological efficacy of the Atole at the individual level. At the level of the whole population, the efficacy of impact was much less, because many children did not participate fully in the supplementation program. The external validity of the biological impact is likely to be good for populations with similar diets and medical care.

* To whom correspondence should be addressed. E-mail: jh48{at}cornell.edu.

Published online 23 December 2009.




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