QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hawley, E. E. Articles by Stephens, D. J. Search for Related Content PubMed Articles by Hawley, E. E. Articles by Stephens, D. J.

The Effect of the Administration of Acid and Alkaline Salts Upon the Ascorbic Acid Content of Guinea Pig Tissues

Departments of Pediatrics, Vital Economics and Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York

In a previous study the authors observed a definite relationship, in humans, between the amount of ascorbic acid found in the urine and the hydrogen ion concentration of the latter. Observations in guinea pigs show that the administration of sodium bicarbonate in amounts sufficient to result in a highly alkaline urine results in an increased concentration of ascorbic acid in the adrenals and liver. It is shown that increased retention of ascorbic acid in the tissues may be at least a partial explanation of the decreased urinary output of ascorbic acid observed in humans in whom the urine had been rendered alkaline by the administration of sodium bicarbonate.

This article has been cited by other articles:

				5: Final Report on the Safety Assessment of Sodium Sesquicarbonate, Sodium Bicarbonate, and Sodium Carbonate International Journal of Toxicology, January 1, 1987; 6(1): 121 - 138. [Abstract] [PDF]

				E. E. HAWLEY and O. PEARSON VITAMIN C AND ITS RELATION TO CATARACT Arch Ophthalmol, June 1, 1938; 19(6): 959 - 967. [Abstract] [PDF]