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Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions

Inositol and Mannose Utilization Rates in Term and Late-Preterm Infants Exceed Nutritional Intakes^1,2

Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045

Nonglucose carbohydrates such as mannose and inositol are important in early growth and development, although little is known about their metabolism. Our aim in this study was to determine the plasma appearance rates (Ra) for mannose and inositol in newborns as an index of utilization and as an improved guide to supplementation practices. We studied late-preterm (n = 9) and term (n = 5) infants (median 34 wk gestation, range 33–41 wk) using a multiple isotope infusion start time protocol to determine Ra for each carbohydrate. The plasma mannose concentration [median (range)] was 69.83 (48.60–111.75) µmol/L and the Ra was 0.59 (0.42–0.98) µmol·kg^–1·min^–1 (854 µmol·kg^–1·d^–1). The plasma inositol concentration was 175.74 (59.71–300.60) µmol/L and Ra was 1.06 (0.33–1.75) µmol·kg^–1·min^–1 (1521 µmol·kg^–1·d^–1). The Ra for mannose and inositol are >10-fold higher than the amounts a breast-fed infant typically ingests, which are 6 µmol·kg^–1·d^–1 mannose and 150 µmol·kg^–1·d^–1 inositol. Thus, for both mannose and inositol, the newborn infant must produce these compounds from glucose at rates sufficient to meet nutritional requirements.

^* To whom correspondence should be addressed. E-mail: laura.brown{at}ucdenver.edu.

Manuscript received 20 April 2009. Initial review completed 27 April 2009. Revision accepted 7 May 2009.

Published online 3 June 2009.

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				S. C. Kalhan Nonglucose Carbohydrates and Infant Nutrition and Metabolism J. Nutr., September 1, 2009; 139(9): 1611 - 1612. [Full Text] [PDF]