QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 139/3/588    most recent jn.108.100339v1 Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lau, C. Articles by Borch-Johnsen, K. Search for Related Content PubMed PubMed Citation Articles by Lau, C. Articles by Borch-Johnsen, K.

---

Nutritional Epidemiology

Dietary Patterns Predict Changes in Two-Hour Post-Oral Glucose Tolerance Test Plasma Glucose Concentrations in Middle-Aged Adults^1,2

³ Steno Diabetes Center, 2820 Gentofte, Denmark; ⁴ Research Centre for Prevention and Health, 2600 Glostrup, Denmark; ⁵ National Food Institute, Technical University of Denmark, 2860 Søborg, Denmark; ⁶ Faculty of Health Sciences, University of Aarhus, 8000 Aarhus, Denmark; and ⁷ Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark

We examined whether the adherence to major dietary patterns at baseline of 5824 nondiabetic Danes (30–60 y) enrolled in the nonpharmacological Inter99 intervention predicted changes in fasting plasma glucose (FPG) and postchallenge 2-h plasma glucose (2h-PG) concentrations during a 5 y period and whether a potential association was dependent on baseline glucose tolerance status. Through principal component analysis, a score for a traditional dietary pattern (characterized by higher intakes of high-fat sandwich spreads, red meat, potatoes, butter and lard, low-fat fish, sandwich meat, and sauces) and a score for a modern dietary pattern (characterized by higher intakes of vegetables, fruit, vegetable oil/vinegar dressing, poultry, pasta, rice, and cereals) were estimated for each person at baseline. Random effect models adjusting for relevant confounders were used to estimate changes in repetitive measures of FPG and 2h-PG. A higher modern score (of 1 SD) predicted an annual decrease in 2h-PG of 0.015 mmol/L (P < 0.01) regardless of glucose tolerance status. For individuals with isolated impaired glucose tolerance, a higher traditional score (of 1 SD) predicted an annual increase in 2h-PG of 0.083 mmol/L (P < 0.0001). In conclusion, glucose tolerance status did not, in general, affect the predictive effect of the dietary patterns. The study suggests that the risk of worsening 2h-PG concentrations may be smaller for individuals with a high modern dietary pattern score characterized by high intakes of vegetables, fruit, vegetable oil/vinegar dressing, poultry, pasta, rice, and cereals.

^* To whom correspondence should be addressed. E-mail: cala{at}steno.dk.

Manuscript received 29 September 2008. Initial review completed 9 November 2008. Revision accepted 31 December 2008.

Published online 21 January 2009.