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Nutrition and Disease

Dietary trans-10, cis-12 Conjugated Linoleic Acid Reduces Early Glomerular Enlargement and Elevated Renal Cyclooxygenase-2 Levels in Young Obese fa/fa Zucker Rats^1–3,

Departments of ⁴ Human Nutritional Sciences, ⁵ Pediatrics and Child Health, ⁶ Animal Science, and ⁷ Physiology, University of Manitoba, Winnipeg, Manitoba, Canada, R3T 2N2

Conjugated linoleic acid (CLA) slows the progression of disease in models of chronic kidney disease. Because obesity is associated with nephropathy and increased renal cyclooxygenase (COX) levels, the effects of dietary CLA on kidney function, morphology, and COX protein levels in the kidneys of young obese (fa/fa) Zucker rats, a model of metabolic syndrome, were examined. In study 1, 6-wk-old fa/fa and lean Zucker rats were given a mixture of CLA isomers (1.5% CLA, wt:wt) or the control diet (CTL) with no CLA for 8 wk. To examine specific isomer effects, study 2 used the same model with the following diets: 0.4% (g/g) cis-9, trans-11 (c9,t11) CLA; 0.4% trans-10, cis-12 (t10,c12) CLA; a combination of these 2 isomers (0.4% each); or CTL diets with no CLA. In study 1, fa/fa rats given the CLA mixture had 11% smaller kidney weights and 28% smaller glomeruli, and feed intake and body weight did not differ from the CTL rats. In study 2, diet also did not affect body weights, but fa/fa rats given a diet containing t10,c12 CLA had 7% lower kidney weights, 20% smaller glomeruli, and 39% lower COX-2 protein levels than CTL rats. In conclusion, dietary t10,c12 CLA reduces the enlargement of glomeruli in young obesity-associated nephropathy and is associated with lower protein levels of renal COX-2. Long-term studies with CLA supplementation are required to determine whether these changes would lead to reduction in development of renal disease associated with obesity.

^* To whom correspondence should be addressed. E-mail: aukema{at}umanitoba.ca.

Manuscript received 24 October 2008. Initial review completed 7 November 2008. Revision accepted 26 November 2008.

Published online 23 December 2008.