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Nutritional Epidemiology

Total Antioxidant Performance Is Associated with Diet and Serum Antioxidants in Participants of the Diet and Physical Activity Substudy of the Jackson Heart Study^1,2

³ Division of Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21025; ⁴ Department of Pharmaceutical Sciences, Pietro Pratesi, Faculty of Pharmacy, University of Milan, 20133 Milan, Italy; ⁵ Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111; ⁶ Department of Family and Consumer Sciences, University of Mississippi, University, MS 38677; and ⁷ The Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS 39216

Total antioxidant performance (TAP) measures antioxidant capacities in both hydrophilic and lipophilic compartments of serum and interactions known to exist between them. Our objective was to assess TAP levels in a subset of Jackson Heart Study (JHS) participants and to examine associations with dietary and total (diet + supplement) intakes of -tocopherol, -tocopherol (diet only), β-carotene, vitamin C, fruit, vegetables, and nuts, and serum concentrations of -tocopherol, -tocopherol, and β-carotene. We conducted a cross-sectional analysis of 420 (mean age 61 y; 254 women) African American men and women participating in the Diet and Physical Activity Sub-Study of the JHS in Jackson, Mississippi. In multivariate-adjusted models, we observed positive associations between total -tocopherol, total and dietary β-carotene, and total vitamin C intakes and TAP levels (P-trend < 0.05). Positive associations were also observed for vegetable, fruit, and total fruit and vegetable intakes (P-trend < 0.05). For serum antioxidant nutrients, -tocopherol but not β-carotene was associated with serum TAP levels. There were inverse associations for serum -tocopherol and TAP levels. Associations for -tocopherol were seen at intake levels much higher than the current Recommended Dietary Allowance. It may, therefore, be prudent to focus on increasing consumption of fruit, vegetables, nuts, and seeds to increase total antioxidant capacity.

^* To whom correspondence should be addressed. E-mail: katherine.tucker{at}tufts.edu.

Manuscript received 27 March 2009. Initial review completed 1 May 2009. Revision accepted 6 August 2009.

Published online 26 August 2009.