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Nutrient Requirements and Optimal Nutrition

Prolonged Intake of Coenzyme Q₁₀ Impairs Cognitive Functions in Mice^1–3,

⁴ Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX 76107; and ⁵ Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089

Coenzyme Q₁₀ (CoQ₁₀) is widely consumed as a dietary supplement to enhance bioenergetic capacity and to ameliorate the debilitative effects of the aging process or certain pathological conditions. Our main purpose in this study was to determine whether CoQ₁₀ intake does indeed attenuate the age-associated losses in motor, sensory, and cognitive functions or decrease the rate of mortality in mice. Mice were fed a control nonpurified diet or that diet containing 0.68 mg/g (low dosage) or 2.6 mg/g (high dosage) CoQ₁₀, starting at 4 mo of age, and were tested for sensory, motor, and cognitive function at 7, 15, and 25 mo of age. Amounts of the ubiquinols CoQ₉H₂ and CoQ₁₀H₂ measured in a parallel study were augmented in the cerebral cortex but not in any other region of the brain. Intake of the low-CoQ₁₀ diet did not affect age-associated decrements in muscle strength, balance, coordinated running, or learning/memory, whereas intake at the higher amount increased spontaneous activity, worsened the age-related losses in acuity to auditory and shock stimuli, and impaired the spatial learning/memory of old mice. The CoQ₁₀ diets did not affect survivorship of mice through 25 mo of age. Our results suggest that prolonged intake of CoQ₁₀ in low amounts has no discernable impact on cognitive and motor functions whereas intake at higher amounts exacerbates cognitive and sensory impairments encountered in old mice. These findings do not support the notion that CoQ₁₀ is a fitness-enhancing or an "antiaging" substance under normal physiological conditions.

^* To whom correspondence should be addressed. E-mail: forsterm{at}hsc.unt.edu.

Manuscript received 20 May 2009. Initial review completed 30 June 2009. Revision accepted 9 August 2009.

Published online 26 August 2009.