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Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions

A Specific Blend of Intact Protein Rich in Aspartate Has Strong Postprandial Glucose Attenuating Properties in Rats¹

Danone Research Centre for Specialised Nutrition, 6700 CA Wageningen, The Netherlands

Three studies were carried out to help define an optimal protein blend for use in a nutritional product for diabetic patients. To this end, we tested the effects of coinfusions of combinations of different types of carbohydrates and proteins on the postprandial glycemic plasma response in healthy rats. Expt. 1 compared the effects of administering different forms of soy protein (intact protein, its hydrolysate, or an equivalent amount of the same amino acids), all in combination with a fixed amount of glucose (Glu), on postprandial Glu and insulin plasma concentrations. Intact soy protein (SI) had stronger insulinogenic properties compared with its hydrolysate but was equally potent in reducing the postprandial Glu response. In Expt. 2, we compared the effect of replacing 50% of the SI with the whey-derived protein -lactalbumin when coingested with maltodextrin as the carbohydrate source. Only the specific aspartate-rich blend of SI and -lactalbumin significantly improved the postprandial Glu response. In Expt. 3, we studied the effect of using the blend of SI and -lactalbumin combined with a slowly digestible carbohydrate. The protein blend was still capable of significantly decreasing the postprandial Glu response even when a slow-release carbohydrate source was included. Combining this aspartate-rich protein blend with a slow-release carbohydrate might therefore lead to a low-glycemic nutritional product beneficial for dietary management in diabetic patients.

^* To whom correspondence should be addressed. E-mail: eline.vanderbeek{at}danone.com.

Manuscript received 30 May 2008. Initial review completed 16 June 2008. Revision accepted 1 July 2008.