![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan
* To whom correspondence should be addressed. E-mail: kuriyama-thk{at}umin.ac.jp.
Although substantial evidence from in vitro and animal studies indicates that green tea preparations inhibit cardiovascular disease processes, the possible protective role of green tea consumption against this disease in humans remains unclear. We conducted a population-based prospective cohort study (the Ohsaki Study) to examine the association between green tea consumption and mortality from cardiovascular disease (CVD), cancer, and all causes with 40,530 persons in Miyagi prefecture, in northern Japan. Previously published work has shown that green tea consumption was inversely associated with mortality from CVD and all causes. The inverse association of mortality from CVD was more pronounced in women (P = 0.08 for interaction with sex). In women, the multivariate hazard ratios (95% confidence intervals) of CVD mortality across increasing green tea consumption categories were 1.00, 0.84 (0.63–1.12), 0.69 (0.52–0.93), 0.69 (0.53–0.90) (P for trend = 0.004). Within CVD mortality, the stronger inverse association was observed for stroke mortality. Because our observational study has found the inverse association, I report here the results of a review of epidemiological evidence from randomized controlled trials (RCT) of the association between green tea or green tea extracts and CVD risk profiles. More than half of the RCT have demonstrated the beneficial effects of green tea on CVD risk profiles. These results from RCT suggest a plausible mechanism for the beneficial effects of green tea and provide substantial support for our observations.
This article has been cited by other articles:
|
|
 |
|
  L. Arab and J. B. Blumberg Proceedings of the Fourth International Scientific Symposium on Tea and Human Health. September 18, 2007. Washington, DC, USA. J. Nutr., August 1, 2008; 138(8): 1526S - 1588S. [Full Text] [PDF]
|
|
|
|
|
|
S. M. Henning, J. J. Choo, and D. Heber Nongallated Compared with Gallated Flavan-3-ols in Green and Black Tea Are More Bioavailable J. Nutr., August 1, 2008; 138(8): 1529S - 1534S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Auger, W. Mullen, Y. Hara, and A. Crozier Bioavailability of Polyphenon E Flavan-3-ols in Humans with an Ileostomy J. Nutr., August 1, 2008; 138(8): 1535S - 1542S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. O. Song and O. K. Chun Tea Is the Major Source of Flavan-3-ol and Flavonol in the U.S. Diet J. Nutr., August 1, 2008; 138(8): 1543S - 1547S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Grassi, A. Aggio, L. Onori, G. Croce, S. Tiberti, C. Ferri, L. Ferri, and G. Desideri Tea, Flavonoids, and Nitric Oxide-Mediated Vascular Reactivity J. Nutr., August 1, 2008; 138(8): 1554S - 1560S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. C. W. Arts A Review of the Epidemiological Evidence on Tea, Flavonoids, and Lung Cancer J. Nutr., August 1, 2008; 138(8): 1561S - 1566S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Hakim, H.-H. S. Chow, and R. B. Harris Green Tea Consumption Is Associated with Decreased DNA Damage among GSTM1-Positive Smokers Regardless of Their hOGG1 Genotype J. Nutr., August 1, 2008; 138(8): 1567S - 1571S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Kelly, M. Gomez-Ramirez, J. L. Montesi, and J. J. Foxe L-Theanine and Caffeine in Combination Affect Human Cognition as Evidenced by Oscillatory alpha-Band Activity and Attention Task Performance J. Nutr., August 1, 2008; 138(8): 1572S - 1577S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Mandel, T. Amit, L. Kalfon, L. Reznichenko, and M. B. H. Youdim Targeting Multiple Neurodegenerative Diseases Etiologies with Multimodal-Acting Green Tea Catechins J. Nutr., August 1, 2008; 138(8): 1578S - 1583S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Stote and D. J. Baer Tea Consumption May Improve Biomarkers of Insulin Sensitivity and Risk Factors for Diabetes J. Nutr., August 1, 2008; 138(8): 1584S - 1588S. [Abstract] [Full Text] [PDF]
|
|
