QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Online Supporting Material Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jaudszus, A. Articles by Hamelmann, E. Search for Related Content PubMed PubMed Citation Articles by Jaudszus, A. Articles by Hamelmann, E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Allergy

---

Nutritional Immunology

Cis-9,trans-11-Conjugated Linoleic Acid Inhibits Allergic Sensitization and Airway Inflammation via a PPAR-Related Mechanism in Mice^1–3,

⁴ Institute of Nutrition, Friedrich Schiller University, 07743 Jena, Germany; ⁵ Department of Pediatric Pneumology, Charité University Medicine, 13353 Berlin, Germany; and ⁶ University Children Hospital, Ruhr University, 44791 Bochum, Germany

^* To whom correspondence should be addressed. E-mail: eckard.hamelmann{at}charite.de.

Milk consumption from early childhood on has been found to be inversely correlated with allergic sensitization and the onset of bronchial asthma. We tested whether cis-9,trans-11-conjugated linoleic acid (c9,t11-CLA), naturally occurring in milk fat, may prevent allergic sensitization and inhibit airway inflammation in a murine asthma model. BALB/c mice were fed a diet enriched in 1 wt% of c9,t11-CLA or a control diet 7 d prior to and for 32 d during sensitization [d 1 and 14, 100 mg/L ovalbumin (OVA) in adjuvant vs. PBS] and airway challenges (d 28–30, 1% OVA in PBS vs. PBS). Subgroups of mice were coadministered 20 µmol/L of the selective PPAR antagonist GW9662 during each OVA challenge. C9,t11-CLA feeding resulted in significantly reduced IgE production and allergen-induced in vivo airway hyperresponsiveness. Further, less mucous plugging of segmental bronchi and significantly reduced interleukin-5 and eosinophils were determined in bronchoalveolar lavage fluids of c9,t11-CLA-fed mice. C9,t11-CLA feeding prevented the downregulation of PPAR mRNA in the lung tissues observed after allergen sensitization and airway challenges in control mice. The inhibitory effects of c9,t11-CLA on airway inflammation were partially prevented by coadministration of GW9962. Further, c9,t11-CLA feeding resulted in a significantly lower concentration of the eicosanoid precursor, arachidonic acid, in tissue lipids. These findings demonstrate that dietary c9,t11-CLA can reduce allergic airway inflammation, most likely via a PPAR-related mechanism and by reducing eicosanoid precursors. They give new insights into the fatty acid-mediated mechanism of immunomodulation and may represent a step toward an attractive novel strategy in the dietary prevention and treatment of allergic asthma.

This article has been cited by other articles:

				C. M. Reynolds, E. Draper, B. Keogh, A. Rahman, A. P. Moloney, K. H. G. Mills, C. E. Loscher, and H. M. Roche A Conjugated Linoleic Acid-Enriched Beef Diet Attenuates Lipopolysaccharide-Induced Inflammation in Mice in Part through PPAR{gamma}-Mediated Suppression of Toll-Like Receptor 4 J. Nutr., December 1, 2009; 139(12): 2351 - 2357. [Abstract] [Full Text] [PDF]

				S. Berdnikovs, H. Abdala-Valencia, C. McCary, M. Somand, R. Cole, A. Garcia, P. Bryce, and J. M. Cook-Mills Isoforms of Vitamin E Have Opposing Immunoregulatory Functions during Inflammation by Regulating Leukocyte Recruitment J. Immunol., April 1, 2009; 182(7): 4395 - 4405. [Abstract] [Full Text] [PDF]

				C. Ramirez-Santana, C. Castellote, M. Castell, M. Rivero, M. Rodriguez-Palmero, A. Franch, and F. J. Perez-Cano Long-Term Feeding of the cis-9,trans-11 Isomer of Conjugated Linoleic Acid Reinforces the Specific Immune Response in Rats J. Nutr., January 1, 2009; 139(1): 76 - 81. [Abstract] [Full Text] [PDF]