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4 Department of Exercise and Nutrition Sciences, University at Buffalo, the State University of New York, Buffalo, NY 14214; 5 Departments of Nutrition and Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115; and 6 Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611
* To whom correspondence should be addressed. E-mail: wessling{at}hsph.harvard.edu.
The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.
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