Journal of Nutrition EB Program 2010 Early Registration

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Filomeni, G.
Right arrow Articles by Ciriolo, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Filomeni, G.
Right arrow Articles by Ciriolo, M. R.
© 2008 American Society for Nutrition J. Nutr. 138:2053-2057, November 2008

Recent Advances in Nutritional Sciences

Molecular Transduction Mechanisms of the Redox Network Underlying the Antiproliferative Effects of Allyl Compounds from Garlic1,2

Giuseppe Filomeni3,4, Giuseppe Rotilio3,4 and Maria R. Ciriolo3,4,*

3 Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy and 4 Research Centre IRCCS San Raffaele - Pisana, 00163, Rome, Italy

* To whom correspondence should be addressed. E-mail: ciriolo{at}bio.uniroma2.it.

Much evidence in the last few years suggests that the antiproliferative effects of various garlic secondary metabolites in in vitro experimental systems are due to redox-based mechanisms. In particular, sulfur-containing allyl compounds have been demonstrated to generate reactive oxygen species and to modify directly the redox state of specific reactive cysteines on protein surfaces. On the basis of such properties, allyl compounds, in particular the ones present in the oil-soluble fraction of garlic extracts, can function as modulators of several redox-mediated signaling pathways related to the activation of mitogen-activated protein kinases, cell cycle, DNA repair, and cell demise. However, even though many in vitro studies have tried to dissect the mechanisms of action of garlic derivatives, research in this field is still incomplete and questions about bioavailability, biotransformation, and pro-oxidant activity are still unanswered. This review discusses recent findings on such aspects, focusing on the chemistry of allyl compounds and their preferential cellular targets as well as on related nutritional aspects.






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Copyright © 2008 by American Society for Nutrition