QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Abdukeyum, G. G. Articles by McLennan, P. L. Search for Related Content PubMed PubMed Citation Articles by Abdukeyum, G. G. Articles by McLennan, P. L.

---

Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions

Dietary (n-3) Long-Chain Polyunsaturated Fatty Acids Inhibit Ischemia and Reperfusion Arrhythmias and Infarction in Rat Heart Not Enhanced by Ischemic Preconditioning^1,2

³ School of Health Sciences, ⁴ Smart Foods Centre, and ⁵ Graduate School of Medicine, University of Wollongong, NSW 2522, Australia

^* To whom correspondence should be addressed. E-mail: petermcl{at}uow.edu.au.

Ischemic preconditioning (IPC) and (n-3) PUFA are both cardioprotective. This study compared effects of dietary fish oil, IPC, and their interactions on heart function and injury during myocardial ischemia and reperfusion. Male Wistar rats were fed diets containing 10% wt:wt fat comprising either 7% high-docosahexaenoic acid (DHA) [22:6(n-3)] tuna fish oil + 3% olive oil [(n-3) PUFA]; 5% sunflower seed oil + 5% olive oil [(n-6) PUFA]; or 7% beef tallow + 3% olive oil [saturated fat (SF)] for 6 wk. In control experiments, isolated perfused hearts were subjected to 30-min regional ischemia and reperfused for 120 min. The IPC hearts were subjected to 3 cycles of 5-min global ischemia before the ischemia and reperfusion. Control (n-3) PUFA hearts had significantly lower heart rate, coronary flow, end diastolic pressure, maximum relaxation rate, and ischemic and reperfusion arrhythmias. In reperfusion, they had greater developed pressure and maximum relaxation rate and smaller infarct (10.9 ± 0.6% ischemic zone, n = 6) than (n-6) PUFA (47.4 ± 0.3%, n = 6) or SF (50.3 ± 0.3%, n = 6). Compared with control, IPC significantly improved heart function and reduced infarct in (n-6) PUFA (11.8 ± 0.4%, n = 6) and SF hearts (13.1 ± 0.1%, n = 6). Heart function and infarct [(n-3) PUFA 9.6 ± 0.1%, n = 6] did not differ among dietary IPC groups. Arrhythmias, significantly reduced by IPC in (n-6) PUFA and SF hearts, were significantly lower in (n-3) PUFA IPC hearts. Dietary fish oil induces a form of preconditioning, nutritional preconditioning, limiting ischemic cardiac injury, and myocardial infarction and endows cardioprotection as powerful as IPC, which provides no additional protection in (n-3) PUFA hearts.

This article has been cited by other articles:

				C. E. Huggins, C. L. Curl, R. Patel, P. L. McLennan, M. L. Theiss, T. Pedrazzini, S. Pepe, and L. M. D. Delbridge Dietary fish oil is antihypertrophic but does not enhance postischemic myocardial function in female mice Am J Physiol Heart Circ Physiol, April 1, 2009; 296(4): H957 - H966. [Abstract] [Full Text] [PDF]