QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McDaniel, S. M. Articles by Schedin, P. Search for Related Content PubMed PubMed Citation Articles by McDaniel, S. M. Articles by Schedin, P.

---

Nutrition and Disease

Whole-Food Sources of Vitamin A More Effectively Inhibit Female Rat Sexual Maturation, Mammary Gland Development, and Mammary Carcinogenesis than Retinyl Palmitate^1,2

³ Department of Medicine, Division of Medical Oncology and Colorado Cancer Center, University of Colorado Health Science Center, Aurora, CO 80010; ⁴ AMC Cancer Research Center, Denver, CO 80214; ⁵ Department of Veterinary Physiology and Pharmacology, Texas A & M, College Station, TX 7784; ⁶ Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL 60612; ⁷ Consultant, ⁸ Department of Preventive Medicine, University of Colorado Health Science Center, Aurora, CO 80010; ⁹ Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523; and ¹⁰ Department of Obstetrics and Gynecology, Division of Basic Science, University of Colorado, Aurora, CO 80010

^* To whom correspondence should be addressed. E-mail: pepper.schedin{at}uchsc.edu.

Previous work using an adolescent rat model for breast cancer showed increased tumor occurrence in rats fed a chemopreventive dose of vitamin A. Preclinical models for nutrient–cancer interactions utilizing defined diets do not replicate the complexity of the human diet and may be inadequate to investigate food patterns associated with reduced cancer risk in humans. To evaluate this concept, the effects of vitamin A on sexual maturation, mammary gland development, and sensitivity to carcinogenesis were determined in the context of a human food-based diet (whole food diet). At 20 d of age (p20), female rats received either a whole-food diet with adequate levels of vitamin A, a diet with a 5.5-fold increase in vitamin A from fruits and vegetables (S diet), or a diet with a 6.2-fold increase in vitamin A provided as retinyl palmitate (RP diet). To determine the effect of dietary intervention on pubertal mammary gland development, the dietary intervention period was restricted to postnatal d 21–63. Rats were injected with 50 mg 1-methyl-1-nitrosourea/kg body weight at d 66. Compared with adolescent rats that consumed the Ad diet, consumption of S and RP diets reduced mammary cancer multiplicity (relative risk 0.7, P 0.002), which was associated with a reduction in alveolar gland development. The S diet suppressed the onset of sexual maturation (P < 0.001) and inhibited markers of mammary alveologenesis more than the RP diet. These data demonstrate that the amount and source of vitamin A consumed by adolescent female rats can influence the onset of puberty, mammary gland alveolar development, and breast cancer risk and highlight the relevance of utilizing whole-food diets to evaluate the role of dietary factors in cancer prevention.

This article has been cited by other articles:

				J. P. Mills, P. W. Simon, and S. A. Tanumihardjo Biofortified Carrot Intake Enhances Liver Antioxidant Capacity and Vitamin A Status in Mongolian Gerbils J. Nutr., September 1, 2008; 138(9): 1692 - 1698. [Abstract] [Full Text] [PDF]