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Department of Internal Medicine, Division of Hematology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201
* To whom correspondence should be addressed. E-mail: prasada{at}karmanos.org.
Zinc deficiency in humans decreases the activity of serum thymulin (a thymic hormone), which is required for maturation of T-helper cells. T-helper 1 (Th1) cytokines are decreased but T-helper 2 (Th2) cytokines are not affected by zinc deficiency in humans. This shift of Th1 to Th2 function results in cell-mediated immune dysfunction. Because IL-2 production (Th1 cytokine) is decreased, this leads to decreased activities of natural-killer cell and T cytolytic cells, which are involved in killing viruses, bacteria, and tumor cells. In humans, zinc deficiency may decrease the generation of new CD4+ T cells from the thymus. In cell culture studies (HUT-78, a Th0 human malignant lymphoblastoid cell line), as a result of zinc deficiency, nuclear factor-
B (NF-
B) activation, phosphorylation of I
B, and binding of NF-
B to DNA are decreased and this results in decreased Th1 cytokine production. In another study, zinc supplementation to humans decreased the gene expression and production of pro-inflammatory cytokines and decreased oxidative stress markers. In HL-60 cells (a human pro-myelocytic leukemia cell line), zinc deficiency increased the levels of TNF-
, IL-1ß, and IL-8 cytokines and mRNA. In these cells, zinc induced A20, a zinc finger protein that inhibited NF-
B activation via tumor necrosis factor receptor associated factor pathway, and this decreased gene expression of pro-inflammatory cytokines and oxidative stress markers. We conclude that zinc has an important role in cell-mediated immune functions and also functions as antiinflammatory and antioxidant agent.
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