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Symposium: Micronutrient Regulation of Host-Pathogen Interactions

Selenium and Vitamin E Status: Impact on Viral Pathogenicity^1–3,

Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599-7461

^* To whom correspondence should be addressed. E-mail: melinda_beck{at}unc.edu.

Selenium (Se), an essential trace element, and vitamin E, a lipid soluble antioxidant, are important mediators for protection against oxidative stress. Recent work has demonstrated that deficiencies in either Se or vitamin E result in increased viral pathogenicity and altered immune responses. Furthermore, deficiencies in either Se or vitamin E results in specific viral mutations, changing relatively benign viruses into virulent ones. Thus, host nutritional status should be considered a driving force for the emergence of new viral strains or newly pathogenic strains of known viruses.

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