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Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions

A High-Fat Meal Increases Cardiovascular Reactivity to Psychological Stress in Healthy Young Adults

¹ University of Calgary, Department of Psychology, Calgary, AB, Canada T2N 1N4; ² Exercise Science, Concordia University, Montreal, PQ, Canada H3G 1M8; and ³ PSU Vascular Health Interventions Lab, Department of Biobehavioral Health, Pennsylvania State University, University Park, PA 16802

^* To whom correspondence should be addressed. E-mail: t.s.campbell{at}ucalgary.ca.

The consumption of high levels of saturated fat over the course of several weeks may lead to exaggerated cardiovascular reactivity. The consumption of a single high-fat meal has been associated with a transient impairment of vascular function. In a randomized, repeated measures, crossover study we tested whether the consumption of a single high-fat meal by healthy, normotensive participants would affect cardiovascular reactivity when compared with an isocaloric, low-fat meal. Thirty healthy participants ate a high-fat (42 g) and a low-fat (1 g) meal on 2 separate occasions, and their cardiovascular response to 2 standard laboratory stressors was measured. Systolic blood pressure, diastolic blood pressure, and total peripheral resistance were greater in participants following the consumption of the high-fat meal relative to the low-fat meal. The findings of the present study are consistent with the hypothesis that even a single high-fat meal may be associated with heightened cardiovascular reactivity to stress and offer insight into the pathways through which a high-fat diet may affect cardiovascular function.

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