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Supplement: Effects of Probiotics and Prebiotics

Milk Peptides and Blood Pressure^1,2

³ Valio Ltd., Research Center, Helsinki, Finland; ⁴ Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland; and ⁵ Foundation for Nutrition Research, Helsinki, Finland

^* To whom correspondence should be addressed. E-mail: riitta.korpela{at}valio.fi.

Epidemiological studies suggest that milk consumption and dietary intake of dairy proteins are inversely related to the risk for hypertension. Also, some intervention studies have shown a blood pressure-lowering effect of milk products and dairy proteins. Milk peptides are formed from milk proteins by enzymatic breakdown by digestive enzymes or by the proteinases formed by lactobacilli during the fermentation of milk. Several milk peptides have been shown to have antihypertensive effects in animal and in clinical studies. The most studied mechanism underlying the antihypertensive effects of milk peptides is inhibition of angiotensin-converting enzyme. Milk peptides may also have other additional mechanisms to lower blood pressure such as opioid-like activities and mineral-binding and antithrombotic properties. The future challenge is to identify the antihypertensive components in milk and their mechanisms of action and thus to find more possibilities for using these constituents and products as a dietary treatment of hypertension.