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Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions

Simultaneous Intake of ß-Glucan and Plant Stanol Esters Affects Lipid Metabolism in Slightly Hypercholesterolemic Subjects¹

Maastricht University, Department of Human Biology, 6200 MD Maastricht, The Netherlands

^* To whom correspondence should be addressed. E-mail: r.mensink{at}hb.unimaas.nl.

Intake of food products rich in water-soluble fiber ß-glucan and products enriched with plant stanol esters lower serum cholesterol. Combining 2 functional food ingredients into one food product may achieve additional reductions of serum cholesterol. Our objective was to investigate the effects of a simultaneous intake of ß-glucan plus plant stanol esters on lipid metabolism in mildly hypercholesterolemic volunteers. In a randomized, controlled, 3-period crossover study, 40 mildly hypercholesterolemic men and women received muesli in random order twice a day for 4 wk, which provided, in total, 5 g control fiber from wheat (control muesli), 5 g oat ß-glucan (ß-glucan muesli), or 5 g oat ß-glucan plus 1.5 g plant stanols (combination muesli). ß-Glucan muesli decreased serum LDL cholesterol by 5.0% compared with control muesli (P = 0.013). Combination muesli reduced LDL cholesterol by 9.6% compared with control muesli (P < 0.001), and by 4.4% compared with ß-glucan muesli (P = 0.036). Serum HDL cholesterol and triacylglycerol concentrations did not differ after the 3 treatments. Compared with control muesli, ß-glucan muesli increased bile acid synthesis (P = 0.043) and decreased cholesterol absorption (P = 0.011). Addition of plant stanols did not influence bile acid synthesis but decreased cholesterol absorption (P < 0.001) and raised cholesterol synthesis (P = 0.016) compared with control muesli, and the plant stanols decreased cholesterol absorption compared with ß-glucan muesli (P = 0.004). The combination muesli decreased serum concentrations of sitostanol compared with control muesli (P = 0.010). Plasma concentrations of lipid-soluble antioxidants did not differ after the 3 treatments. ß-Glucan muesli effectively lowered serum LDL cholesterol concentrations. The addition of plant stanol esters to ß-glucan-enriched muesli further lowered serum LDL cholesterol, although effects were slightly less than predicted.

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