Journal of Nutrition OpenSOurce Diets- www.ResearchDiets.com

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pitel, S.
Right arrow Articles by Coste, T. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pitel, S.
Right arrow Articles by Coste, T. C.
© 2007 The American Society for Nutrition J. Nutr. 137:368-372, February 2007

Nutrition and Disease

At Low Doses, a {gamma}-Linolenic Acid-Lipoic Acid Conjugate Is More Effective Than Docosahexaenoic Acid-Enriched Phospholipids in Preventing Neuropathy in Diabetic Rats1

Séverine Pitel2, Denis Raccah2, Alain Gerbi3, Gérard Pieroni3, Philippe Vague2 and Thierry C. Coste2,*

2 UPRES EA 2193, Aix-Marseille Université, Faculté de Médecine, IPHM-IFR 125, Marseille, F-13385 France; 3 INSERM U476, Nutrition Humaine et Lipides, Marseille, F-13385, France; INRA UMR 1260, Marseille, F-13385, France; and Aix-Marseille Université, Faculté de Médecine, IPHM-IFR 125, Marseille, F-13385 France

* To whom correspondence should be addressed. E-mail: thierry.coste{at}medecine.univ-mrs.fr.

A deficiency in essential fatty acid metabolism has been reported in diabetes. Nutritional supplementations with (n-6) or (n-3) PUFA have differential efficiency on parameters of diabetic neuropathy, including nerve conduction velocity (NCV) and nerve blood flow (NBF). The aim of this study was to compare the neuroprotective effects of {gamma}-linolenic acid (GLA)-lipoic acid (LA) conjugate (GLA-LA) and docosahexaenoic acid (DHA)-enriched phospholipids (PL) supplementations on NCV and NBF. Streptozotocin-induced diabetic (D) and control (C) rats were supplemented for 8 wk with either DHA-enriched PL at a dose of 30 mg · kg–1 · d–1 (DDHA and CDHA) or with corn oil enriched with GLA-LA at a dose of 30 mg · kg–1 · d–1 (DGLA and CGLA). Moreover, a C and D group received no supplementation. After 8 wk, NCV (–30%) and NBF (–50%) were lower in the D group than in the C group. Supplementation with GLA-LA totally prevented the decrease in NCV and NBF in the DGLA group, in which values did not differ from group C. Supplementation with DHA only partially prevented the decrease in NCV in the DDHA group, in which value was different from groups C and D and did not affect NBF. We conclude that at the low doses used, supplementation with GLA-LA is more effective than supplementation with DHA in preventing experimental diabetic neuropathy. The difference could be due in part to an antioxidant protective effect of LA on GLA.






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]