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Inulin and Oligofructose: Health Benefits and Claims-A Critical Review

Current Data with Inulin-Type Fructans and Calcium, Targeting Bone Health in Adults^1–3,

Unité de Nutrition Humaine (UMR1019), Equipe Alimentation Squelette et Métabolismes INRA Theix, 63122 Saint-Genès Champanelle, France

^* To whom correspondence should be addressed. E-mail: coxam{at}clermont.inra.fr.

In humans, there is increasing evidence that the colon can absorb nutritionally significant amounts of calcium, and this process may be susceptible to dietary manipulation by fermentable substrates, especially inulin-type fructans. Inulin-type fructans can modulate calcium absorption because they are resistant to hydrolysis by mammalian enzymes and are fermented in the large intestine to produce short-chain fatty acids, which in turn reduce luminal pH and modify calcium speciation, and hence solubility, or exert a direct effect on the mucosal transport pathway. Quite a few intervention studies showed an improvement of calcium absorption in adolescents or young adults by inulin-type fructans. In the same way, a positive effect has been reported in older women.

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