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Ingestive Behavior and Neurosciences

Yeast Proteins Enhance Satiety in Rats^1,2

³ Institut National de la Recherche Agronomique, Unité INRA-INAPG de Physiologie de la Nutrition et du Comportement Alimentaire, Institut National Agronomique Paris-Grignon, F75231 Paris Cedex 05, France and ⁴ Bio-Springer, 94704 Maisons Alfort Cedex, France

^* To whom correspondence should be addressed. E-mail: fromenti{at}inapg.fr.

This study was designed to characterize the suppressant effect of yeast protein and purified peptides on energy intake. For this purpose, 5 experiments were carried out using adult male Wistar rats. Rats that consumed ad libitum a standard yeast protein diet ate significantly less and were leaner over 21 d than rats that consumed ad libitum a standard milk protein diet (Expt. 1). Moreover, rats fed a high yeast protein load reduced their next meal and daily energy intake more than rats fed any other well-balanced, amino acid, high protein load (soy, total milk protein, or wheat gluten) and more than those fed a wheat starch diet (Expt. 2). Purified peptides from the yeast protein extract produced similar effects on subsequent energy intake (Expt. 3). Study of the behavioral satiety sequence showed that rats consuming P14-y or P55-y diets ad libitum did not acquire a conditioned food aversion (Expt. 4). Finally, a preliminary study of gastric emptying in rats fed yeast protein loads showed that yeast protein was emptied more rapidly through the pylorus than total milk protein during a meal, which may induce satiety (Expt. 5). Taken together, these experiments show that yeast proteins enhance satiety in rats more than other proteins.

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				R. Faipoux, D. Tome, S. Gougis, N. Darcel, and G. Fromentin Proteins Activate Satiety-Related Neuronal Pathways in the Brainstem and Hypothalamus of Rats J. Nutr., June 1, 2008; 138(6): 1172 - 1178. [Abstract] [Full Text] [PDF]