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2 Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan; 3 Department of Food Management, School of Food, Agricultural and Environment Sciences, Miyagi University, Sendai 982-0215, Japan; 4 Faculty of Nursing and Nutrition, Siebold University of Nagasaki, Nagasaki 851-2195, Japan; 5 Plantech Research Institute, Yokohama, Japan; 6 Department of Bioresource Science, Faculty of Agriculture, Tamagawa University, Tokyo, Japan; 7 The Nisshin OilliO Group, Shinkawa 1-chome, Chuo-ku, Tokyo 104-8285, Japan; and 8 Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan
* To whom correspondence should be addressed. E-mail: tsuduki{at}myu.ac.jp.
We showed previously that 
-eleostearic acid (-ESA; 9Z11E13E-18:3) is converted to 9Z11E-conjugated linoleic acid (CLA) in rats through a 
13-saturation reaction. To investigate this further, we examined the absorption and metabolism of -ESA in rat intestine using a lipid absorption assay in lymph from the thoracic duct. In this study, we used 4 test oils [tung oil, perilla oil, CLA-triacylglycerol (TG), and pomegranate seed oil, containing -ESA, -linolenic acid (LnA; 9Z12Z15Z-18:3), CLA, and punicic acid (PA; 9Z11E13Z-18:3), respectively]. Emulsions containing the test oils were administered to rats, and lymph from the thoracic duct was collected over 24 h. The positional and geometrical isomerism of CLA produced by PA metabolism was determined using GC-electron impact (EI)-MS and 13C-NMR, respectively; the product was confirmed to be 9Z11E-CLA. A part of -ESA and PA was converted to 9Z11E-CLA 1 h after administration; therefore the lymphatic recoveries of -ESA and PA were modified by the amount of recovered CLA. Cumulative recovery of CLA, -ESA, and PA was lower than that of LnA only during h 1 (P < 0.05), and cumulative recovery of -ESA and PA was significantly lower than that of LnA and CLA for 8 h (P < 0.05). Therefore, the absorption rate was LnA > CLA > -ESA = PA. The conversion ratio of -ESA to 9Z11E-CLA was higher than that of PA to 9Z11E-CLA over 24 h (P < 0.05). These results indicated that -ESA and PA are slowly absorbed in rat intestine, and a portion of these fatty acids is quickly converted to 9Z11E-CLA.
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