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Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions

Diacylglycerol Oil Does Not Affect Portal Vein Transport of Nonesterified Fatty Acids but Decreases the Postprandial Plasma Lipid Response in Catheterized Pigs¹

Janni Brogaard Kristensen^*,2, Henry Jørgensen and Huiling Mu^*

^* Biochemistry and Nutrition Group, BioCentrum-DTU and Center for Advanced Food Studies, Technical University of Denmark, DK-2800 Lyngby, Denmark and Department of Animal Health, Welfare and Nutrition, Danish Institute of Agricultural Sciences, Research Centre Foulum, DK-8830 Tjele, Denmark

² To whom correspondence should be addressed. E-mail: jannibk{at}gmail.com.

Studies have shown several beneficial effects of dietary diacylglycerol oil (DAG oil), but the mechanism behind these effects is still not clear. One hypothesis is that an increase in portal vein transport of nonesterified fatty acids (NEFA) with subsequent oxidation in the liver might be responsible for the positive effects. We examined the portal vein transport of NEFA and other lipid related variables, in response to DAG and triacylglycerol (TAG) bolus feeding and a bolus of standard pig feed in 4 portal vein and mesenteric artery catheterized pigs. Also, the effect of the boluses on postprandial lipid variables was examined. Portal vein transport of NEFA did not differ when pigs were administered the 2 oil bolus diets, consistent with the similar portal plasma concentrations of oleic and linolenic acids during h 1 after feeding. Glycerol, on the contrary, was transported by the portal vein to a much higher degree after intake of DAG oil (P < 0.001; 20, 40, and 60 min). The postprandial arterial TAG response at 5 and 6 h postprandially was significantly lower after the DAG bolus intake. Analysis of AUC for the 6-h postprandial period of selected and total fatty acids showed a lower concentration of vaccenic acid (P = 0.002) after the DAG bolus diet. In conclusion, DAG bolus feeding did not increase the portal transport of NEFA, but it did increase the portal transport of glycerol and lower the postprandial lipid concentration in arterial plasma.

KEY WORDS: • diacylglycerols • portal vein transport • nonesterified fatty acids • lipid absorption • postprandial lipid response