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© 2006 American Society for Nutrition J. Nutr. 136:992-997, April 2006

Nutrition and Disease

Diets Rich in Conjugated Linoleic Acid and Vaccenic Acid Have No Effect on Blood Pressure and Isobaric Arterial Elasticity in Healthy Young Men1

Marianne Raff*,2, Tine Tholstrup*, Kristen Sejrsen{dagger}, Ellen M. Straarup** and Niels Wiinberg{ddagger}

* Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark; {dagger} The Danish Institute of Agricultural Sciences, Research Centre Foulum, Tjele, Denmark; ** The Biochemistry and Nutrition Group, BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark; and {ddagger} Department of Clinical Physiology, Frederiksberg Hospital, Frederiksberg, Denmark

2 To whom correspondence should be addressed. E-mail: mrf{at}kvl.dk.

The objective of this study was to examine the effect on blood pressure (BP) and isobaric arterial elasticity (AE), as a measure of arterial health, of a commercial mixture of conjugated linoleic acids (CLA) and of milk fat produced through livestock feeding to have a high content of vaccenic acid (VA). Healthy young men (n = 60) with a BMI of 22.5 ± 2 kg/m2 (mean ± SD) participated in this double-blind, randomized, 5-wk, parallel intervention study. The participants substituted 115 g of their daily fat intake with fat from 1 of 3 test diets: 1) CLA-diet rich in CLA (4.7 g/d of c9,t11- and t10,c12-CLA isomers in equal amounts); 2) VA-diet rich in VA (3.6 g/d); or 3) C-diet, a control diet with a low content of VA and CLA. All test diets were based on milk fat. BP and AE (measured by an oscillometric method) were measured before and after the intervention period. The effects of the test diets did not differ on any outcome variable: e.g., systolic- and diastolic blood pressure (SBP and DBP), pulse pressure (PP), isobaric arterial compliance (AC), distensibility (AD), or volume (AV). In conclusion, diets rich in milk fat and either CLA or VA have no effect on BP or AE indices in healthy young men compared with a control diet.

KEY WORDS: • conjugated linoleic acids • vaccenic acid • milk trans fatty acids • arterial health • blood pressure




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M. Raff, T. Tholstrup, S. Basu, P. Nonboe, M. T. Sorensen, and E. M. Straarup
A Diet Rich in Conjugated Linoleic Acid and Butter Increases Lipid Peroxidation but Does Not Affect Atherosclerotic, Inflammatory, or Diabetic Risk Markers in Healthy Young Men
J. Nutr., March 1, 2008; 138(3): 509 - 514.
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