QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Haque, A. M. Articles by Shido, O. Search for Related Content PubMed PubMed Citation Articles by Haque, A. M. Articles by Shido, O.

---

Ingestive Behavior and Neurosciences

Long-Term Administration of Green Tea Catechins Improves Spatial Cognition Learning Ability in Rats¹

Abdul M. Haque^*, Michio Hashimoto^*,2, Masanori Katakura^*, Yoko Tanabe^*, Yukihiko Hara and Osamu Shido^*

^* Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan and Mitsui Norin Company, Limited, Shinjuku-ku, Tokyo 160-8381, Japan

² To whom correspondence should be addressed. E-mail: michio1{at}med.shimane-u.ac.jp.

Green tea catechins confer potent biological properties including antioxidation and free-radical scavenging. We investigated the effect of long-term oral administration of green tea catechins (Polyphenon^R E, PE: EGCG 63%; EC 11%; EGC 6%; ECG 6%) mixed with water on the spatial cognition learning ability of young rats. The learning ability of rats administered PE (0%, 0.1%, 0.5%) for 26 wk was assessed in the partially baited 8-arm radial maze. Relative to controls, those administered PE had improved reference and working memory–related learning ability. They also had lower plasma concentrations of lipid peroxides and greater plasma ferric-reducing antioxidation power than controls. Furthermore, rats administered PE had lower hippocampus reactive oxygen species concentrations than controls. We suggest that this improvement in spatial cognitive learning ability is due to the antioxidative activity of green tea catechins.

KEY WORDS: • green tea catechins • memory learning • antioxidants • rats

This article has been cited by other articles:

				J. W. Lee, Y. K. Lee, J. O. Ban, T. Y. Ha, Y. P. Yun, S. B. Han, K. W. Oh, and J. T. Hong Green Tea (-)-Epigallocatechin-3-Gallate Inhibits {beta}-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-{kappa}B Pathways in Mice J. Nutr., October 1, 2009; 139(10): 1987 - 1993. [Abstract] [Full Text] [PDF]

				C. Auger, W. Mullen, Y. Hara, and A. Crozier Bioavailability of Polyphenon E Flavan-3-ols in Humans with an Ileostomy J. Nutr., August 1, 2008; 138(8): 1535S - 1542S. [Abstract] [Full Text] [PDF]

				S. A. Mandel, T. Amit, L. Kalfon, L. Reznichenko, and M. B. H. Youdim Targeting Multiple Neurodegenerative Diseases Etiologies with Multimodal-Acting Green Tea Catechins J. Nutr., August 1, 2008; 138(8): 1578S - 1583S. [Abstract] [Full Text] [PDF]

				T.-P. Ng, L. Feng, M. Niti, E.-H. Kua, and K.-B. Yap Tea consumption and cognitive impairment and decline in older Chinese adults Am. J. Clinical Nutrition, July 1, 2008; 88(1): 224 - 231. [Abstract] [Full Text] [PDF]

				D. L. McKay and J. B. Blumberg Roles for Epigallocatechin Gallate in Cardiovascular Disease and Obesity: An Introduction J. Am. Coll. Nutr., August 1, 2007; 26(4): 362S - 365S. [Abstract] [Full Text] [PDF]

				H. van Praag, M. J. Lucero, G. W. Yeo, K. Stecker, N. Heivand, C. Zhao, E. Yip, M. Afanador, H. Schroeter, J. Hammerstone, et al. Plant-Derived Flavanol (-)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice J. Neurosci., May 30, 2007; 27(22): 5869 - 5878. [Abstract] [Full Text] [PDF]