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© 2006 American Society for Nutrition J. Nutr. 136:1043-1047, April 2006

Ingestive Behavior and Neurosciences

Long-Term Administration of Green Tea Catechins Improves Spatial Cognition Learning Ability in Rats1

Abdul M. Haque*, Michio Hashimoto*,2, Masanori Katakura*, Yoko Tanabe*, Yukihiko Hara{dagger} and Osamu Shido*

* Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan and {dagger} Mitsui Norin Company, Limited, Shinjuku-ku, Tokyo 160-8381, Japan

2 To whom correspondence should be addressed. E-mail: michio1{at}med.shimane-u.ac.jp.

Green tea catechins confer potent biological properties including antioxidation and free-radical scavenging. We investigated the effect of long-term oral administration of green tea catechins (PolyphenonR E, PE: EGCG 63%; EC 11%; EGC 6%; ECG 6%) mixed with water on the spatial cognition learning ability of young rats. The learning ability of rats administered PE (0%, 0.1%, 0.5%) for 26 wk was assessed in the partially baited 8-arm radial maze. Relative to controls, those administered PE had improved reference and working memory–related learning ability. They also had lower plasma concentrations of lipid peroxides and greater plasma ferric-reducing antioxidation power than controls. Furthermore, rats administered PE had lower hippocampus reactive oxygen species concentrations than controls. We suggest that this improvement in spatial cognitive learning ability is due to the antioxidative activity of green tea catechins.

KEY WORDS: • green tea catechins • memory learning • antioxidants • rats




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