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© 2006 American Society for Nutrition J. Nutr. 136:852S-854S, March 2006

Supplement: Significance of Garlic and Its Constituents in Cancer and Cardiovascular Disease

Allyl Sulfur Compounds from Garlic Modulate Aberrant Crypt Formation1,2

Sharon A. Ross*,3, John W. Finley{dagger} and John A. Milner*

* Nutritional Sciences Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Rockville, MD 20892-7328 and {dagger} A. M. Todd, Inc., Montgomeryville, PA 18936

3 To whom correspondence should be addressed: rosssha{at}mail.nih.gov.

The health benefits of garlic, including inhibition of carcinogenesis, are supported by several epidemiologic and laboratory findings. Garlic's sulfur components have been reported to suppress experimentally induced tumor incidence in several organs, including the colon. Studies in humans also suggest that dietary garlic constituents reduce the risk of colorectal adenomatous polyps, which are considered precursors to colon cancer. Aberrant crypt foci (ACF) are proposed to be early preneoplastic lesions of adenoma-carcinoma in humans and chemically induced colon cancer in rodents. In preclinical studies, both water- and lipid-soluble allyl sulfur compounds arising from processed garlic inhibited ACF. The response to these allyl sulfur compounds appears to depend on several factors, including the speciation, quantity, and duration provided.

KEY WORDS: • Aberrant crypt foci • colorectal cancer • garlic • allyl sulfur compounds




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