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Supplement: Significance of Garlic and Its Constituents in Cancer and Cardiovascular Disease

A Factorial Trial Including Garlic Supplements Assesses Effect in Reducing Precancerous Gastric Lesions^1,2

Mitchell H. Gail^*,3 and Wei-Cheng You

^* Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 and Beijing Institute of Cancer Research, Haidian District, Beijing, China 100036

³ To whom correspondence should be addressed. E-mail: gailm{at}mail.nih.gov.

The Shandong Intervention Trial was a factorial, double-blind, placebo-controlled trial to determine whether any of 3 interventions, alone or in combination, could reduce the prevalence of precancerous gastric lesions in Linqu County, Shandong Province, China, a region with high gastric cancer mortality rates and a prevalence in adults of Helicobacter pylori of 67%. The 3 interventions were one-time treatment with amoxicillin and omeprazole for Helicobacter pylori infection, and long-term administration of a garlic supplement (aged garlic extract and steam-distilled garlic oil) and a vitamin supplement (vitamins E and C and selenium). This paper describes the design and initial findings on treatment compliance, completeness of follow-up data, and eradication of Helicobacter pylori.

KEY WORDS: • gastric cancer • Helicobacter pylori • garlic • vitamins

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