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Supplement: Significance of Garlic and Its Constituents in Cancer and Cardiovascular Disease

Antiglycation Properties of Aged Garlic Extract: Possible Role in Prevention of Diabetic Complications^1,2

School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester M1 5GD, UK

³ To whom correspondence should be addressed. E-mail: n.ahmed{at}mmu.ac.uk.

Diabetes mellitus is a common endocrine disorder characterized by hyperglycemia and long-term complications affecting the eyes, nerves, blood vessels, skin, and kidneys. Increased glycation of proteins and accumulation of advanced glycation endproducts (AGEPs) have been implicated in the pathogenesis of diabetic complications. Glycation and AGEP formation are also accompanied by formation of free radicals via autoxidation of glucose and glycated proteins. Compounds with combined antiglycation and antioxidant properties may offer therapeutic potential. Recent studies suggest that aged garlic extract (AGE) inhibits formation of AGEPs in vitro and formation of glycation-derived free radicals. S-Allylcysteine, a key component of aged garlic, is a potent antioxidant and can inhibit AGEP formation. Aged garlic extract and S-allylcysteine deserve more attention and should be investigated to see whether they can reduce AGEPs in vivo.

KEY WORDS: • aged garlic extract • diabetes mellitus • hyperglycemia • S-allylcysteine • glycation