QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shimomura, Y. Articles by Mawatari, K. Search for Related Content PubMed PubMed Citation Articles by Shimomura, Y. Articles by Mawatari, K.

---

Supplement: Branched-Chain Amino Acids in Exercise

Nutraceutical Effects of Branched-Chain Amino Acids on Skeletal Muscle^1,2,3

Yoshiharu Shimomura^*,4, Yuko Yamamoto^*, Gustavo Bajotto^*, Juichi Sato, Taro Murakami^**, Noriko Shimomura, Hisamine Kobayashi and Kazunori Mawatari

^* Department of Materials Science and Engineering, Nagoya Institute of Technology, Nagoya, Japan; Department of General Medicine, Nagoya University Hospital, Nagoya, Japan; ^** Department of Nutrition, Faculty of Wellness, Chukyo Women's University, Ohbu, Japan; Chukyo Junior College, Mizunami, Japan; and Ajinomoto Co., Inc., Tokyo, Japan

⁴ To whom correspondence should be addressed. E-mail: shimomura.yoshiharu{at}nitech.ac.jp.

BCAA catabolism in skeletal muscle is regulated by the branched-chain -keto acid dehydrogenase (BCKDH) complex, located at the second step in the BCAA catabolic pathway. The activity of the BCKDH complex is regulated by a phosphorylation/dephosphorylation cycle. Almost all of BCKDH complex in skeletal muscle under normal and resting conditions is in an inactive/phosphorylated state, which may contribute to muscle protein synthesis and muscle growth. Exercise activates the muscle BCKDH complex, resulting in enhanced BCAA catabolism. Therefore, exercise may increase the BCAA requirement. It has been reported that BCAA supplementation before exercise attenuates the breakdown of muscle proteins during exercise in humans and that leucine strongly promotes protein synthesis in skeletal muscle in humans and rats, suggesting that a BCAA supplement may attenuate muscle damage induced by exercise and promote recovery from the damage. We have examined the effects of BCAA supplementation on delayed-onset muscle soreness (DOMS) and muscle fatigue induced by squat exercise in humans. The results obtained showed that BCAA supplementation prior to squat exercise decreased DOMS and muscle fatigue occurring for a few days after exercise. These findings suggest that BCAAs may be useful for muscle recovery following exercise.

KEY WORDS: • BCKDH complex • exercise • branched-chain amino acids • muscle fatigue • muscle soreness

This article has been cited by other articles:

				Y. Zhang, K. Guo, R. E. LeBlanc, D. Loh, G. J. Schwartz, and Y.-H. Yu Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms Diabetes, June 1, 2007; 56(6): 1647 - 1654. [Abstract] [Full Text] [PDF]