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Supplement: Understanding Tolerable Upper Intake Levels

A Critical Assessment of the Upper Intake Levels for Infants and Children^1,2

Departments of Paediatrics, Nutritional Sciences, and Public Health Sciences and Centre for International Health, University of Toronto, Toronto, Ontario, Canada and Division of Gastroenterology, Hepatology and Nutrition, and Programs in Metabolism, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

³ To whom correspondence should be addressed. E-mail: stanley.zlotkin{at}sickkids.ca.

The dietary reference intake (DRI) committees of the Food and Nutrition Board of the Institute of Medicine were charged with establishing DRIs for all of the essential nutrients, including fat and energy. These reference values are quantitative estimates of the nutrient intakes to be used to plan and assess the diets of healthy people. The reference values include both recommended intakes and tolerable upper intake levels (ULs). The ULs are defined as "the highest level of daily nutrient intake that is likely to pose no risk of adverse health effects to almost all individuals in the general population." As intake increases above the UL, the risk of adverse effects increases. The term "tolerable intake" was chosen to avoid the implication of a possible beneficial effect. Instead, the term is intended to connote a level of intake that can, with a high probability, be tolerated biologically. Yet, with intakes above the ULs, the risk of adverse health effects increases. Thus, there is no obvious benefit for healthy individuals to consume quantities of nutrients above the UL.

KEY WORDS: • dietary reference intakes (DRIs) • upper intake levels (ULs) • tolerable intakes • infants and children.

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