QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zaripheh, S. Articles by Erdman, J. W. Search for Related Content PubMed PubMed Citation Articles by Zaripheh, S. Articles by Erdman, J. W., Jr.

---

Nutrient Metabolism

The Biodistribution of a Single Oral Dose of [¹⁴C]-Lycopene in Rats Prefed Either a Control or Lycopene-Enriched Diet^1,2

Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801

³To whom correspondence should be addressed. E-mail: jwerdman{at}uiuc.edu.

Lycopene (lyc) has emerged as a primary candidate for dietary interventions of prostate cancer; however, research regarding its absorption, tissue distribution, and metabolism is limited. Previously, we evaluated the biodistribution (3–168 h) of a single oral dose of ¹⁴C-lyc in rats prefed lyc for 30 d. The liver was the primary depot for lyc, and the ¹⁴C and ¹⁴C-polar products appeared in tissues as early as 3 h after dosing. In the current study, F344 rats (n = 48) were randomly assigned to 1 of 4 groups prefed either a control or lyc-enriched diet (0.25 g lyc/kg diet) for 30 d and killed at 5 or 24 h after receiving a single oral dose of ¹⁴C-lyc. The percentage of the ¹⁴C dose absorbed at 24 h was lower (5.5 ± 0.5%) in lyc-prefed (LP) rats than in control-prefed (CP) rats (6.9 ± 0.4%, P < 0.04). Hepatic total ¹⁴C and ¹⁴C-lyc in CP rats was greater than in LP rats at 24 h (P < 0.005). A portion of ¹⁴C was delivered to extrahepatic tissues as early as 5 h, irrespective of diet. Of the tissues analyzed, an increase in the percentage in ¹⁴C-polar products occurred between 5 and 24 h only in the prostate and seminal vesicles, suggesting increased accumulation of ¹⁴C-polar products in these tissues, irrespective of prior dietary treatment. These data suggest that lyc absorption, tissue uptake, and catabolism were affected by prefeeding and that lyc can be partially taken up by extrahepatic tissues from the postprandial triglyceride-rich fraction.

KEY WORDS: • lycopene • lycopene metabolites • tissue biodistribution • prostate • rats

This article has been cited by other articles:

				K. Canene-Adams, B. L. Lindshield, S. Wang, E. H. Jeffery, S. K. Clinton, and J. W. Erdman Jr. Combinations of Tomato and Broccoli Enhance Antitumor Activity in Dunning R3327-H Prostate Adenocarcinomas Cancer Res., January 15, 2007; 67(2): 836 - 843. [Abstract] [Full Text] [PDF]

				M. Gajic, S. Zaripheh, F. Sun, and J. W. Erdman Jr. Apo-8'-Lycopenal and Apo-12'-Lycopenal Are Metabolic Products of Lycopene in Rat Liver J. Nutr., June 1, 2006; 136(6): 1552 - 1557. [Abstract] [Full Text] [PDF]

				S. Zaripheh, T. Y. Nara, M. T. Nakamura, and J. W. Erdman Jr. Dietary Lycopene Downregulates Carotenoid 15,15'-Monooxygenase and PPAR-{gamma} in Selected Rat Tissues J. Nutr., April 1, 2006; 136(4): 932 - 938. [Abstract] [Full Text] [PDF]