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Nutritional Epidemiology

Higher Dietary Intake of Lignans Is Associated with Better Cognitive Performance in Postmenopausal Women¹

Oscar H. Franco^*,, Huibert Burger^*, Corinne E. I. Lebrun^*,**, Petra H. M. Peeters^*, Steven W. J. Lamberts^**, Diederick E. Grobbee^* and Yvonne T. Van Der Schouw^*,2

^* Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands; Department of Public Health and ^** Department of Internal Medicine III, Erasmus Medical Center Rotterdam, The Netherlands

²To whom correspondence should be addressed. E-mail: Y.T.vanderSchouw{at}umcutrecht.nl.

Data on the relation between phytoestrogens and cognitive function are still sparse. The purpose of this study was to examine the relation between the dietary intake of phytoestrogens and cognitive function in healthy postmenopausal women consuming a Western diet. We conducted a community-based survey among 394 postmenopausal women. Isoflavone and lignan intake was calculated from a validated FFQ. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). Data were analyzed using logistic regression with intact cognitive function defined as a score 26 as the outcome variable. After adjustment for confounders, increasing dietary lignans intake was associated with better performance on the MMSE [OR and (95%CI): 1.49 (0.94–2.38)]. Results were most pronounced in women who were 20–30 y postmenopausal [2.02 (1.11–3.71)]. Isoflavone intake was not related to cognitive function. From our results we conclude that higher dietary intake of lignans is associated with better cognitive function in postmenopausal women.

KEY WORDS: • diet • lignans • global cognitive performance • postmenopausal women