QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lim, S.-Y. Articles by Salem, N. Search for Related Content PubMed PubMed Citation Articles by Lim, S.-Y. Articles by Salem, N., Jr

---

Nutritional Neurosciences

Lead Exposure and (n-3) Fatty Acid Deficiency during Rat Neonatal Development Alter Liver, Plasma, and Brain Polyunsaturated Fatty Acid Composition¹

Sun-Young Lim, John D. Doherty^* and Norman Salem, Jr^,2

Division of Ocean Science, Korea Maritime University, Busan, Korea; ^* U.S. Environmental Protection Agency, Office of Pesticide Programs, Health Effects Division, Washington, DC; and Laboratory of Membrane Biochemistry and Biophysics, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD

²To whom correspondence should be addressed. E-mail: nsalem{at}niaaa.nih.gov.

Lead (Pb) exposure has been reported to increase arachidonic (AA) and docosahexaenoic (DHA) acids. To determine whether Pb effects on fatty acid composition are influenced by dietary (n-3) fatty acid restriction, weanling female rats were fed either an (n-3)-adequate or -deficient diet to maturity and mated. At parturition, dams in each group were subdivided to receive either 0.2% Pb or Na-acetate in their drinking water during lactation only. Pups were analyzed for fatty acid content in liver, plasma, and brain at either 3 or 11 wk. The (n-3)-deficient diets markedly decreased total (n-3) fatty acids, and increased total (n-6) fatty acids including both AA and docosapentaenoic (n-6) in each compartment (P < 0.05). The main effects of Pb were in the livers of weanling rats where there was a 56% loss in total fatty acid concentration concurrent with increased relative percentages of AA and DHA. Thus, because there was a greater percentage of liver nonessential fatty acid lost relative to the essential fatty acids (EFA), there was no net change in AA concentration. There was a diet x Pb interaction for a decrease in liver DHA concentration evident only in the (n-3)-adequate group. There were also diet x Pb interactions in plasma at 11 wk and in brain at 3 wk. These data are consistent with the hypothesis of a Pb-induced increase in fatty acid catabolism, perhaps as a source of energy.

KEY WORDS: • arachidonic acid • docosahexaenoic acid • fatty acid composition • lead • (n-3) fatty acid deficiency • Pb

This article has been cited by other articles:

				C.-W. Chen and H.-H. Cheng A Rice Bran Oil Diet Increases LDL-Receptor and HMG-CoA Reductase mRNA Expressions and Insulin Sensitivity in Rats with Streptozotocin/Nicotinamide-Induced Type 2 Diabetes J. Nutr., June 1, 2006; 136(6): 1472 - 1476. [Abstract] [Full Text] [PDF]

				S.-Y. Lim, J. D. Doherty, K. McBride, N. J. Miller-Ihli, G. N. Carmona, K. D. Stark, and N. Salem Jr Lead Exposure and (n-3) Fatty Acid Deficiency during Rat Neonatal Development Affect Subsequent Spatial Task Performance and Olfactory Discrimination J. Nutr., May 1, 2005; 135(5): 1019 - 1026. [Abstract] [Full Text] [PDF]