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Symposium: Nutrient Disease Relationships: Closing the Scientific Knowledge Gap

Scientific Evidence to Support a Vitamin E and Heart Disease Health Claim: Research Needs^1,2

Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA and VA Northern California Health Care System, Mather, CA

³To whom correspondence should be addressed. E-mail: ishwarlal.jialal{at}ucdmc.ucdavis.edu.

In addition to epidemiologic studies suggesting a benefit for high intakes of -tocopherol, studies following supplementation in humans have clearly shown that -tocopherol decreases lipid peroxidation, platelet aggregation, and functions as a potent anti-inflammatory agent. However, prospective human clinical trials with -tocopherol alone and in combination with other antioxidants have been largely negative. In this review, we critically appraise the various clinical trials and provide recommendations for future research.

KEY WORDS: • antioxidant • -tocopherol • vitamin E • cardiovascular disease • clinical trials

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