![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Department of Environmental Toxicology and The Institute of Environmental and Human Health, Texas Tech University System, Lubbock, TX;
* Fudan University, Shanghai, China; and
Tulane University School of Medicine, New Orleans, LA
2To whom correspondence should be addressed. E-mail: js.wang{at}ttu.edu.
Lycopene is a promising chemopreventive agent for human prostate cancer. To test the hypothesis that the effect of lycopene on prostate cancer is stage specific in the process of carcinogenesis, inhibitory effects of natural lycopene on the proliferation of 3 different human prostate carcinoma cell lines were examined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Lycopene more potently inhibited the growth of the androgen-independent DU145 and PC-3 cells than androgen-dependent LNCaP cells. The 50% inhibitory concentration of lycopene for these cell lines was 26.6 µmol/L for DU145, 40.3 µmol/L for PC-3, and 168.5 µmol/L for LNCaP. We also studied the inhibitory effect of lycopene on the growth rate of DU145 tumor xenografts in BALB/c male nude mice. The tumor growth rate was inhibited by 55.6 and 75.8% in mice treated with 100 and 300 mg/kg lycopene, respectively, compared with controls. In addition, no tumors formed in 1 mo in mice treated with DU145 cells that had been pretreated with 20 µmol/L lycopene; however, they did form when DU145 cells were not pretreated. Flow cytometry revealed that lycopene caused DU145 cells to accumulate in the G0/G1 phase and to undergo apoptosis in a dose-dependent manner. The rate of apoptosis was up to 42.4% lower in DU145 cells treated with 32 µmol/L lycopene compared with the untreated control cells. These results suggest that lycopene may specifically inhibit the growth of androgen-independent prostate cancers.
KEY WORDS: • lycopene • prostate cancer cells • chemoprevention
This article has been cited by other articles:
|
|
 |
|
  X. Liu, J. D. Allen, J. T. Arnold, and M. R. Blackman Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells Carcinogenesis, April 1, 2008; 29(4): 816 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-S. Huang, J.-W. Liao, and M.-L. Hu Lycopene Inhibits Experimental Metastasis of Human Hepatoma SK-Hep-1 Cells in Athymic Nude Mice J. Nutr., March 1, 2008; 138(3): 538 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Canene-Adams, B. L. Lindshield, S. Wang, E. H. Jeffery, S. K. Clinton, and J. W. Erdman Jr. Combinations of Tomato and Broccoli Enhance Antitumor Activity in Dunning R3327-H Prostate Adenocarcinomas Cancer Res., January 15, 2007; 67(2): 836 - 843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gajic, S. Zaripheh, F. Sun, and J. W. Erdman Jr. Apo-8'-Lycopenal and Apo-12'-Lycopenal Are Metabolic Products of Lycopene in Rat Liver J. Nutr., June 1, 2006; 136(6): 1552 - 1557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Limpens, F. H. Schroder, C. M. A. de Ridder, C. A. Bolder, M. F. Wildhagen, U. C. Obermuller-Jevic, K. Kramer, and W. M. van Weerden Combined Lycopene and Vitamin E Treatment Suppresses the Growth of PC-346C Human Prostate Cancer Cells in Nude Mice J. Nutr., May 1, 2006; 136(5): 1287 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Clinton Tomatoes or Lycopene: a Role in Prostate Carcinogenesis? J. Nutr., August 1, 2005; 135(8): 2057S - 2059S. [Full Text] [PDF]
|
|
