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Nutrition and Cancer

Dietary Vitamin E Does Not Inhibit the Promotion of Liver Carcinogenesis by Polychlorinated Biphenyls in Rats^1,2

Howard P. Glauert^*,,**,3, Zijing Lu^*,, Amita Kumar^*, R. Petruta Bunaciu^*, Sandip Patel^*, Job C. Tharappel^*, Divinia N. Stemm, Hans-Joachim Lehmler^,4, Eun Y. Lee^,, Larry W. Robertson^*,,4 and Brett T. Spear^*,,,

^* Graduate Center for Nutritional Sciences, Graduate Center for Toxicology, ^** Department of Nutrition and Food Science, Department of Pathology and Laboratory Medicine, and Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY 40506

³To whom correspondence should be addressed. E-mail: hglauert{at}uky.edu.

In this study, the effect of dietary vitamin E on the hepatic tumor-promoting activity of PCB-77 and PCB-153 in female Sprague-Dawley rats (175–200 g) was investigated. One week after diethylnitrosamine injection, rats were fed purified diets containing 10, 50, or 250 mg/kg vitamin E in the form of -tocopheryl acetate. Starting 1 wk later, we injected rats i.p. with vehicle (corn oil) or PCB-77 or PCB-153 (300 µmol/kg) every 14 d for 4 injections. All rats were killed 10 d after the last PCB injection. The number and volume of placental glutathione S-transferase (PGST)–positive foci were increased by PCB-77 but not by PCB-153. Vitamin E did not affect the induction of PGST-positive foci. PCB-77, but not PCB-153, increased hepatic NF-B activity. In conclusion, dietary vitamin E supplementation does not protect against the induction of altered hepatic focal lesions by PCBs.

KEY WORDS: • polychlorinated biphenyls • vitamin E • altered hepatic foci • NF-B

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