QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ikeda, I. Articles by Kakuda, T. Search for Related Content PubMed PubMed Citation Articles by Ikeda, I. Articles by Kakuda, T.

---

Biochemical and Molecular Actions of Nutrients

Tea Catechins with a Galloyl Moiety Suppress Postprandial Hypertriacylglycerolemia by Delaying Lymphatic Transport of Dietary Fat in Rats

Ikuo Ikeda¹, Koichi Tsuda, Yuko Suzuki^*, Makoto Kobayashi^*, Tomonori Unno^*, Hiroko Tomoyori, Hitomi Goto, Yayoi Kawata, Katsumi Imaizumi, Ayumu Nozawa^* and Takami Kakuda^*

Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812-8581, Japan; ^* Central Research Institute, ITO EN, Ltd., Shizuoka 421-0516, Japan; and Department of Environmental and Symbiotic Sciences, Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto 862-8502, Japan

¹To whom correspondence should be addressed. E-mail: iikeda{at}agr.kyushu-u.ac.jp.

Tea catechins, (–)-epicatechin (EC), (–)-epigallocatechin (EGC), (–)-epicatechin gallate (ECG), and (–)-epigallocatechin gallate (EGCG), have been shown to be epimerized to (–)-catechin (C), (–)-gallocatechin (GC), (–)-catechin gallate (CG), and (–)-gallocatechin gallate (GCG), respectively, during heat treatment. In this study, we examined the effect of tea catechins rich in ECG and EGCG and heat-treated tea catechins rich in CG and GCG on postprandial hypertriacylglycerolemia in rats. Both tea catechins and heat-treated tea catechins suppressed postprandial hypertriacylglycerolemia. Lymphatic recovery of ¹⁴C-trioleoylglycerol in rats cannulated in the thoracic duct was delayed by the administration of tea catechins and heat-treated tea catechins. Tea catechins and heat-treated tea catechins had the same effect on all variables tested. These catechin preparations dose-dependently inhibited the activity of pancreatic lipase in vitro. When purified catechins were used, only those with a galloyl moiety inhibited the activity of pancreatic lipase. These results suggest that catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by slowing down triacylglycerol absorption through the inhibition of pancreatic lipase. Because postprandial hypertriacylglycerolemia is a risk factor for coronary heart disease, our results suggest that catechins with a galloyl moiety may prevent this disease.

KEY WORDS: • catechins • postprandial hypertriacylglycerolemia • pancreatic lipase • rats • tea

This article has been cited by other articles:

				C. Auger, W. Mullen, Y. Hara, and A. Crozier Bioavailability of Polyphenon E Flavan-3-ols in Humans with an Ileostomy J. Nutr., August 1, 2008; 138(8): 1535S - 1542S. [Abstract] [Full Text] [PDF]

				T. Tsuzuki, Y. Kawakami, R. Abe, K. Nakagawa, K. Koba, J. Imamura, T. Iwata, I. Ikeda, and T. Miyazawa Conjugated Linolenic Acid Is Slowly Absorbed in Rat Intestine, but Quickly Converted to Conjugated Linoleic Acid J. Nutr., August 1, 2006; 136(8): 2153 - 2159. [Abstract] [Full Text] [PDF]