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Nutrient Metabolism

Colonic Fermentation of Inulin Increases Whole-Body Acetate Turnover in Dogs

Unité de Nutrition et Endocrinologie, Ecole Nationale Vétérinaire de Nantes, 44307 Nantes Cedex 3, France

¹To whom correspondence should be addressed. E-mail: pnguyen{at}vet-nantes.fr.

ABSTRACT

Metabolism of acetate from colonic fermentation was investigated in dogs. Beagle dogs (n = 9) were fed a control diet for 17 d followed by a 3% inulin–enriched diet (from chicory) for 4 and 21 d. On 3 occasions, the dogs were administered simultaneously infusions of [1-¹³C]acetate i.v. and [1,2-¹³C₂]acetate intrarectally. Peripheral acetate concentration and turnover did not change over time after consumption of an inulin-enriched diet for 4 d. After 21 d of consuming the inulin-enriched diet, the whole-body acetate turnover increased significantly by 31% from (mean ± SEM) 15.6 ± 2.2 to 20.4 ± 2.9 µmol/(kg · min) without a change in concentration. The rate of colonic acetate production that reached the peripheral circulation was 4.8 ± 1.8 µmol/(kg · min). However, no [1,2-¹³C₂]acetate tracer was recovered in the peripheral circulation. The fraction of oxidized tracer was higher in the gut (64 ± 3%) than in peripheral circulation (46 ± 3%) in dogs fed an inulin-enriched diet for 21 d. In conclusion, colonic fermentation of inulin occurred and indirectly stimulated whole-body acetate turnover in dogs fed an inulin-enriched diet for 21 d.

KEY WORDS: • acetate • colonic fermentation • dogs • stable isotope