![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269
2To whom correspondence should be addressed. E-mail: maria-luz.fernandez{at}uconn.edu.
Dietary polyphenols have been shown to possess cardioprotective effects. For example, the most noted role of grape polyphenols is in the French Paradox, in which a diet high in saturated fat accompanied by regular consumption of red wine is associated with a low risk of coronary heart disease (CHD). Initially, the paradox was thought to be driven by the postulated major action of grape polyphenols in inhibiting LDL oxidation. Although many studies have shown inhibitory effects of polyphenols on LDL oxidation, there have been an equal number of studies that showed a null effect on this variable. Although there are contrasting viewpoints on the effects of polyphenols on LDL oxidation variables, there is increasing evidence that these compounds possess additional cardioprotective functions including altering hepatic cholesterol absorption, triglyceride assembly and secretion, the processing of lipoproteins in plasma, and inflammation. It is the purpose of this review to examine recent information on the multiple functions of dietary polyphenols, with an emphasis on grape polyphenols, in decreasing the risk of CHD by improving plasma lipid profiles and reducing inflammation.
KEY WORDS: • dietary polyphenols • lipoprotein metabolism • cytokines • coronary heart disease • inflammation
This article has been cited by other articles:
|
|
 |
|
  A. M. Kivela, E. Kansanen, H.-K. Jyrkkanen, T. Nurmi, S. Yla-Herttuala, and A.-L. Levonen Enterolactone Induces Heme Oxygenase-1 Expression through Nuclear Factor-E2-Related Factor 2 Activation in Endothelial Cells J. Nutr., July 1, 2008; 138(7): 1263 - 1268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. A. Jenkins, C. W. C. Kendall, A. Marchie, A. R. Josse, T. H. Nguyen, D. A. Faulkner, K. G. Lapsley, and J. Blumberg Almonds Reduce Biomarkers of Lipid Peroxidation in Older Hyperlipidemic Subjects J. Nutr., May 1, 2008; 138(5): 908 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Castilla, A. Davalos, J. L. Teruel, F. Cerrato, M. Fernandez-Lucas, J. L. Merino, C. C. Sanchez-Martin, J. Ortuno, and M. A Lasuncion Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients Am. J. Clinical Nutrition, April 1, 2008; 87(4): 1053 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. H. Woo, M. M. Y. Waye, S. K. W. Tsui, S. T. W. Yeung, and C. H. K. Cheng Andrographolide Up-Regulates Cellular-Reduced Glutathione Level and Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury J. Pharmacol. Exp. Ther., April 1, 2008; 325(1): 226 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. G. Athyros, E. N. Liberopoulos, D. P. Mikhailidis, A. A. Papageorgiou, E. S. Ganotakis, K. Tziomalos, A. I. Kakafika, A. Karagiannis, S. Lambropoulos, and M. Elisaf Association of Drinking Pattern and Alcohol Beverage Type With the Prevalence of Metabolic Syndrome, Diabetes, Coronary Heart Disease, Stroke, and Peripheral Arterial Disease in a Mediterranean Cohort Angiology, January 1, 2008; 58(6): 689 - 697. [Abstract] [PDF]
|
|
|
|
 |
|
 J. W. E. Rush, J. Quadrilatero, A. S. Levy, and R. J. Ford Chronic Resveratrol Enhances Endothelium-Dependent Relaxation but Does Not Alter eNOS Levels in Aorta of Spontaneously Hypertensive Rats Experimental Biology and Medicine, June 1, 2007; 232(6): 814 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-m. Liu, M. A. Azam, K. J. Peyton, D. Ensenat, A. N. Keswani, H. Wang, and W. Durante Butylated hydroxyanisole stimulates heme oxygenase-1 gene expression and inhibits neointima formation in rat arteries Cardiovasc Res, April 1, 2007; 74(1): 169 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-I. Covas, K. Nyyssonen, H. E. Poulsen, J. Kaikkonen, H.-J. F. Zunft, H. Kiesewetter, A. Gaddi, R. de la Torre, J. Mursu, H. Baumler, et al. The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med, September 5, 2006; 145(5): 333 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. VIRMANI, Z. BINIENDA, S. ALI, and F. GAETANI Links between Nutrition, Drug Abuse, and the Metabolic Syndrome. Ann. N.Y. Acad. Sci., August 1, 2006; 1074: 303 - 314. [Abstract] [Full Text] [PDF]
|
|
