QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Aktas, H. Articles by Halperin, J. A. Search for Related Content PubMed PubMed Citation Articles by Aktas, H. Articles by Halperin, J. A.

---

Supplement: Nutrition and Gene Regulation

Translational Regulation of Gene Expression by -3 Fatty Acids^1,2

Laboratory for Translational Research and Department of Medicine, Harvard Medical School and Brigham and Woman’s Hospital, Boston, MA 02115

³To whom correspondence should be addressed. E-mail: jose_halperin{at}hms.harvard.edu.

The incidence of some cancers shows dramatic variations around the world that cannot be explained by ethnic or racial differences. Observational studies point to a negative correlation between consumption of fish and incidence of breast and prostate cancer. In vitro and animal model studies indicate that (-3) PUFAs present at high concentrations in marine animals inhibit proliferation of cancer cells and growth of tumors. However, how these fatty acids inhibit cell proliferation and tumor growth is a matter of considerable debate. In this review we summarize our recent work indicating that Ca⁺⁺ depletion mediated phosphorylation of the alpha subunit of eIF2 and subsequent inhibition of translation initiation account for the anti-cancer activity of (-3) PUFAs.

KEY WORDS: • (-3) PUFA • translation initiation • ternary complex • cancer

This article has been cited by other articles:

				C. H. Jakobsen, G. L. Storvold, H. Bremseth, T. Follestad, K. Sand, M. Mack, K. S. Olsen, A. G. Lundemo, J. G. Iversen, H. E. Krokan, et al. DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis J. Lipid Res., October 1, 2008; 49(10): 2089 - 2100. [Abstract] [Full Text] [PDF]

				L. A. Sauer, R. T. Dauchy, D. E. Blask, J. A. Krause, L. K. Davidson, and E. M. Dauchy Eicosapentaenoic Acid Suppresses Cell Proliferation in MCF-7 Human Breast Cancer Xenografts in Nude Rats via a Pertussis Toxin-Sensitive Signal Transduction Pathway J. Nutr., September 1, 2005; 135(9): 2124 - 2129. [Abstract] [Full Text] [PDF]