![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA
2To whom correspondence should be addressed. E-mail: Email: ghotamis{at}hsph.harvard.edu.
Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins with the task of protecting a cell’s delicate lipid balance. Yet they fail when faced with metabolic or inflammatory stress, turning the cytosol into an inhospitable environment with less than ideal outcomes. This review will focus on how FABPs direct lipid traffic and simultaneously control inflammatory and metabolic pathways under the pressures of the Metabolic Syndrome.
KEY WORDS: • fatty acid binding protein (FABP) • Metabolic Syndrome • inflammation • obesity • insulin resistance
This article has been cited by other articles:
|
|
 |
|
  D. C.Y. Yeung, Y. Wang, A. Xu, S. C.W. Cheung, N. M.S. Wat, D. Y.T. Fong, C. H.Y. Fong, M.T. Chau, P. C. Sham, and K. S.L. Lam Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis Eur. Heart J., July 4, 2008; (2008) ehn295v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W.K. Tso, A. Xu, P. C. Sham, N. M.S. Wat, Y. Wang, C. H.Y. Fong, B. M.Y. Cheung, E. D. Janus, and K. S.L. Lam Serum Adipocyte Fatty Acid Binding Protein as a New Biomarker Predicting the Development of Type 2 Diabetes: A 10-year prospective study in a Chinese cohort Diabetes Care, October 1, 2007; 30(10): 2667 - 2672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.C.Y. Yeung, A. Xu, C.W.S. Cheung, N.M.S. Wat, M.H. Yau, C.H.Y. Fong, M.T. Chau, and K.S.L. Lam Serum Adipocyte Fatty Acid-Binding Protein Levels Were Independently Associated With Carotid Atherosclerosis Arterioscler. Thromb. Vasc. Biol., August 1, 2007; 27(8): 1796 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sarov-Blat, R. S. Kiss, B. Haidar, N. Kavaslar, M. Jaye, M. Bertiaux, K. Steplewski, M. R. Hurle, D. Sprecher, R. McPherson, et al. Predominance of a Proinflammatory Phenotype in Monocyte-Derived Macrophages From Subjects With Low Plasma HDL-Cholesterol Arterioscler. Thromb. Vasc. Biol., May 1, 2007; 27(5): 1115 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Xu, A. W.K. Tso, B. M.Y. Cheung, Y. Wang, N. M.S. Wat, C. H.Y. Fong, D. C.Y. Yeung, E. D. Janus, P. C. Sham, and K. S.L. Lam Circulating Adipocyte-Fatty Acid Binding Protein Levels Predict the Development of the Metabolic Syndrome: A 5-Year Prospective Study Circulation, March 27, 2007; 115(12): 1537 - 1543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. O. Enwonwu and C. S. Ritchie Nutrition and inflammatory markers J Am Dent Assoc, January 1, 2007; 138(1): 70 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, D. K. Pritchard, X. Wang, D. R. Park, R. E. Bumgarner, S. M. Schwartz, and W. C. Liles cDNA microarray analysis reveals fundamental differences in the expression profiles of primary human monocytes, monocyte-derived macrophages, and alveolar macrophages J. Leukoc. Biol., January 1, 2007; 81(1): 328 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Rolph, T. R. Young, B. O. V. Shum, C. Z. Gorgun, C. Schmitz-Peiffer, I. A. Ramshaw, G. S. Hotamisligil, and C. R. Mackay Regulation of Dendritic Cell Function and T Cell Priming by the Fatty Acid-Binding Protein aP2 J. Immunol., December 1, 2006; 177(11): 7794 - 7801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C TSIOTRA and C. TSIGOS Stress, the Endoplasmic Reticulum, and Insulin Resistance Ann. N.Y. Acad. Sci., November 1, 2006; 1083(1): 63 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Cao, K. Maeda, C. Z. Gorgun, H.-J. Kim, S.-Y. Park, G. I. Shulman, J. K. Kim, and G. S. Hotamisligil Regulation of metabolic responses by adipocyte/ macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes, July 1, 2006; 55(7): 1915 - 1922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Tuncman, E. Erbay, X. Hom, I. De Vivo, H. Campos, E. B. Rimm, and G. S. Hotamisligil A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease PNAS, May 2, 2006; 103(18): 6970 - 6975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Xu, Y. Wang, J. Y. Xu, D. Stejskal, S. Tam, J. Zhang, N. M.S. Wat, W. K. Wong, and K. S.L. Lam Adipocyte Fatty Acid-Binding Protein Is a Plasma Biomarker Closely Associated with Obesity and Metabolic Syndrome Clin. Chem., March 1, 2006; 52(3): 405 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Hotamisligil Role of Endoplasmic Reticulum Stress and c-Jun NH2-Terminal Kinase Pathways in Inflammation and Origin of Obesity and Diabetes Diabetes, December 1, 2005; 54(suppl_2): S73 - S78. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Y. Chan, Q. Chen, A. G. G. Go, E. K. Y. Lam, and E. T. S. Li Reduced Adiposity in Bitter Melon (Momordica charantia)-Fed Rats Is Associated with Increased Lipid Oxidative Enzyme Activities and Uncoupling Protein Expression J. Nutr., November 1, 2005; 135(11): 2517 - 2523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Makowski, K. C. Brittingham, J. M. Reynolds, J. Suttles, and G. S. Hotamisligil The Fatty Acid-binding Protein, aP2, Coordinates Macrophage Cholesterol Trafficking and Inflammatory Activity: MACROPHAGE EXPRESSION OF aP2 IMPACTS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR {gamma} AND I{kappa}B KINASE ACTIVITIES J. Biol. Chem., April 1, 2005; 280(13): 12888 - 12895. [Abstract] [Full Text] [PDF]
|
|
