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Nutrient Metabolism

Cis-9, Trans-11 and Trans-10, Cis-12 Conjugated Linoleic Acid Isomers Do Not Modify Body Composition in Adult Sedentary or Exercised Rats¹

Philippe Patureau Mirand², Marie-Agnès Arnal-Bagnard, Laurent Mosoni, Yannick Faulconnier^*, Jean-Michel Chardigny and Yves Chilliard^*

Unité Nutrition et Métabolisme Protéique and ^* Unité Recherches sur les Herbivores, Centre Inra de Clermont-Ferrand-Theix, 63122 Theix, France and Unité Nutrition Lipidique, Centre Inra de Dijon, 21065 Dijon, France

²To whom correspondence should be addressed. E-mail: patureau{at}clermont.inra.fr.

Dietary CLA isomers were shown to reduce adipose tissues in growing animals, mainly in mice, but their effects in adult animals remain unclear. This study was conducted to determine whether these effects depend on the isomer fed, on physical activity, or on the initial level of body fat. Male Wistar rats (4 mo old) were fed for 6 wk diets containing either no CLA, the cis-9, trans-11 CLA isomer (10 g/kg), the trans-10, cis-12 CLA isomer (10 g/kg), or both isomers (10 g/kg each). Half of the rats were assigned to exercise by treadmill running (1 h/d, 22 m/min). The initial body fat level was normal (12.7%) in a first trial, and high (18.9%) in a second trial. Chemical and anatomical body compositions were determined by chemical analysis and organ dissection. In both trials, the CLA diets, whatever the isomer, had no effect on food intake and body weight changes, on body chemical composition (fat, protein and water contents or gains), or on the body anatomical composition (weights or gains in epididymal and perirenal adipose tissues, in liver and in 4 muscles). There was no interaction between CLA treatment and physical activity. In conclusion, adult male rats do not appear to be responsive to the fat-to-lean partitioning effect of CLA described in growing rats. This was not affected by exercise or initial body fat level.

KEY WORDS: • CLA isomers • exercise • body composition • rats

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