QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Boudry, G. Articles by Sève, B. Search for Related Content PubMed PubMed Citation Articles by Boudry, G. Articles by Sève, B.

---

Nutrient Metabolism

Weaning Induces Both Transient and Long-Lasting Modifications of Absorptive, Secretory, and Barrier Properties of Piglet Intestine^1,2

Institut National de la Recherche Agronomique (INRA)-UMRVP, St-Gilles, France

³To whom correspondence should be addressed. E-mail: Gaelle.boudry{at}rennes.inra.fr.

This study investigated intestinal physiology of piglets at weaning. Piglets (n = 60) weaned at 21 d were food deprived for 2 d and then tube-fed using 2 different diets (a conventional diet vs. a wheat-enriched diet). They were slaughtered at d 0, 2, 5, 8, or 15 postweaning. Jejunum, ileum, and colon were mounted in Ussing chambers. In addition, segments of the proximal jejunum of 4 growing pigs were studied 35 d after weaning. Secretory function was assessed by basal short-circuit current (Isc) and secretagogue-stimulated Isc. Glucose absorption was measured by the increase in Isc after the addition of glucose. Epithelial barrier function was measured by transmucosal resistance (R) and horseradish peroxidase (HRP) fluxes across the epithelium. There were no significant differences between the pigs fed the 2 diets for any of the parameters studied. As already reported, a transient villous atrophy was observed. At the same time, we observed an increased basal Isc in jejunum and colon, increased glucose absorption and a dramatic drop of R in jejunum. These parameters had returned to preweaning values by d 5. Weaning was also followed by long-lasting modifications. In jejunum, responses to the secretagogues and glucose absorption were decreased at wk 2 after weaning and were not different between d 15 and 35. Ileal transmucosal resistance increased on d 5 and was stable thereafter. HRP flux in jejunum declined on d 2 and stayed at this low level throughout the experiment. We conclude that weaning induces transient dramatic changes in intestinal physiology but is also a period of maturation of the intestine.

KEY WORDS: • pigs • weaning • intestinal permeability • electrolyte transport • glucose absorption

This article has been cited by other articles:

				M. Lessard, G. Boudry, B. Seve, I. P. Oswald, and J.-P. Lalles Intestinal Physiology and Peptidase Activity in Male Pigs Are Modulated by Consumption of Corn Culture Extracts Containing Fumonisins J. Nutr., July 1, 2009; 139(7): 1303 - 1307. [Abstract] [Full Text] [PDF]

				F. Liu, J. Yin, M. Du, P. Yan, J. Xu, X. Zhu, and J. Yu Heat-stress-induced damage to porcine small intestinal epithelium associated with downregulation of epithelial growth factor signaling J Anim Sci, June 1, 2009; 87(6): 1941 - 1949. [Abstract] [Full Text] [PDF]

				E. G. Manzanilla, J. F. Perez, M. Martin, J. C. Blandon, F. Baucells, C. Kamel, and J. Gasa Dietary protein modifies effect of plant extracts in the intestinal ecosystem of the pig at weaning J Anim Sci, June 1, 2009; 87(6): 2029 - 2037. [Abstract] [Full Text] [PDF]

				G. Boudry, V. Douard, J. Mourot, J.-P. Lalles, and I. Le Huerou-Luron Linseed Oil in the Maternal Diet during Gestation and Lactation Modifies Fatty Acid Composition, Mucosal Architecture, and Mast Cell Regulation of the Ileal Barrier in Piglets J. Nutr., June 1, 2009; 139(6): 1110 - 1117. [Abstract] [Full Text] [PDF]

				P. Liu, X. S. Piao, S. W. Kim, L. Wang, Y. B. Shen, H. S. Lee, and S. Y. Li Effects of chito-oligosaccharide supplementation on the growth performance, nutrient digestibility, intestinal morphology, and fecal shedding of Escherichia coli and Lactobacillus in weaning pigs J Anim Sci, October 1, 2008; 86(10): 2609 - 2618. [Abstract] [Full Text] [PDF]

				N. K. Gabler, J. D. Spencer, D. M. Webel, and M. E. Spurlock In Utero and Postnatal Exposure to Long Chain (n-3) PUFA Enhances Intestinal Glucose Absorption and Energy Stores in Weanling Pigs J. Nutr., November 1, 2007; 137(11): 2351 - 2358. [Abstract] [Full Text] [PDF]

				A. J. Moeser, K. A. Ryan, P. K. Nighot, and A. T. Blikslager Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs Am J Physiol Gastrointest Liver Physiol, August 1, 2007; 293(2): G413 - G421. [Abstract] [Full Text] [PDF]

				G. Biagi, A. Piva, M. Moschini, E. Vezzali, and F. X. Roth Performance, intestinal microflora, and wall morphology of weanling pigs fed sodium butyrate J Anim Sci, May 1, 2007; 85(5): 1184 - 1191. [Abstract] [Full Text] [PDF]

				S. Pie, A. Awati, S. Vida, I. Falluel, B. A. Williams, and I. P. Oswald Effects of added fermentable carbohydrates in the diet on intestinal proinflammatory cytokine-specific mRNA content in weaning piglets J Anim Sci, March 1, 2007; 85(3): 673 - 683. [Abstract] [Full Text] [PDF]

				A. Piva, V. Pizzamiglio, M. Morlacchini, M. Tedeschi, and G. Piva Lipid microencapsulation allows slow release of organic acids and natural identical flavors along the swine intestine J Anim Sci, February 1, 2007; 85(2): 486 - 493. [Abstract] [Full Text] [PDF]

				A. J. Moeser, C. V. Klok, K. A. Ryan, J. G. Wooten, D. Little, V. L. Cook, and A. T. Blikslager Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig Am J Physiol Gastrointest Liver Physiol, January 1, 2007; 292(1): G173 - G181. [Abstract] [Full Text] [PDF]