![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Departments of Human Nutrition and Food Science and * Biological Sciences, Cal Poly Pomona University, Pomona, CA 91768
3To whom correspondence should be addressed. E-mail: macaudill{at}csupomona.edu.
Population-based studies report differences in folate status indicators among Mexican American (MA), African American (AA) and Caucasian (CA) women. It is unclear, however, whether these differences are due to variations in dietary folate intake. The present study was designed to investigate the influence of ethnicity/race on folate status parameters in MA, AA, and CA women (18–45 y; n = 14 in each group) under conditions of strictly controlled folate intake. In addition, the adequacy of the 1998 folate U.S. recommended dietary allowance (RDA), 400 µg/d as dietary folate equivalents (DFE), for non-Caucasian women was assessed. Subjects (n = 42) with the methylenetetrahydrofolate reductase 677 CC genotype consumed a low-folate diet (135 µg DFE/d) for 7 wk followed by repletion with 400 (7 MA, 7 AA, 7 CA) or 800 µg DFE/d (7 MA, 7 AA, 7 CA) for 7 wk. AA women had lower (P 
0.05) blood folate concentrations and excreted less (P 0.05) urinary folate throughout folate depletion and repletion with 400 and/or 800 µg DFE/d compared with MA and/or CA women. MA women had lower (P 0.05) plasma total homocysteine (tHcy) throughout folate depletion and during repletion with 400 µg DFE/d relative to the other ethnic/racial groups. Repletion with the 1998 folate U.S. RDA led to normal blood folate and plasma tHcy for all 3 ethnic/racial groups. Collectively, these data demonstrate that ethnicity/race is an important determinant of folate status under conditions of strictly controlled dietary folate intake and support the adequacy of the 1998 folate U.S. RDA for the 3 largest ethnic/racial groups in the United States.
KEY WORDS: • ethnicity • race • homocysteine • folate • humans • RDA
This article has been cited by other articles:
|
|
 |
|
  J. Hung, C. M. Abratte, W. Wang, R. Li, D. J. Moriarty, and M. A. Caudill Ethnicity and Folate Influence Choline Status in Young Women Consuming Controlled Nutrient Intakes J. Am. Coll. Nutr., April 1, 2008; 27(2): 253 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Ganji and M. R. Kafai Trends in Serum Folate, RBC Folate, and Circulating Total Homocysteine Concentrations in the United States: Analysis of Data from National Health and Nutrition Examination Surveys, 1988-1994, 1999-2000, and 2001-2002 J. Nutr., January 1, 2006; 136(1): 153 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Beagle, T. L. Yang, J. Hung, E. A. Cogger, D. J. Moriarty, and M. A. Caudill The Glycine N-Methyltransferase (GNMT) 1289 C->T Variant Influences Plasma Total Homocysteine Concentrations in Young Women after Restricting Folate Intake J. Nutr., December 1, 2005; 135(12): 2780 - 2785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M Pfeiffer, S. P Caudill, E. W Gunter, J. Osterloh, and E. J Sampson Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000 Am. J. Clinical Nutrition, August 1, 2005; 82(2): 442 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Yang, J. Hung, M. A. Caudill, T. F. Urrutia, A. Alamilla, C. A. Perry, R. Li, H. Hata, and E. A. Cogger A Long-Term Controlled Folate Feeding Study in Young Women Supports the Validity of the 1.7 Multiplier in the Dietary Folate Equivalency Equation J. Nutr., May 1, 2005; 135(5): 1139 - 1145. [Abstract] [Full Text] [PDF]
|
|
