QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Fair, D. E. Articles by Aukema, H. M. Search for Related Content PubMed PubMed Citation Articles by Fair, D. E. Articles by Aukema, H. M.

---

Nutrient Metabolism
Research Communication

Dietary Soy Protein Attenuates Renal Disease Progression After 1 and 3 Weeks in Han:SPRD-cy Weanling Rats^1,2

Denise E. Fair^*, Malcolm R. Ogborn^*,, Hope A. Weiler^*,, Neda Bankovic-Calic, Evan P. Nitschmann, Shirley C. Fitzpatrick-Wong^* and Harold M. Aukema^*,,3

Departments of ^* Human Nutritional Sciences and Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada

³To whom correspondence should be addressed. E-mail: aukema{at}umanitoba.ca.

Compared with casein, dietary soy protein slows disease progression in animal models of chronic renal injury. To determine whether dietary soy protein feeding can alter early disease progression, male Han:SPRD-cy rats (n = 87) in a very early stage of chronic kidney disease were fed soy protein compared with casein-based diets for 1 or 3 wk. Kidneys were assessed for fibrosis, cyst growth, fatty acid composition and prostaglandin E₂ (PGE₂) production. Soy protein feeding significantly reduced renal fibrosis by 22% (P = 0.0347) and 38% (P = 0.0102) after 1 and 3 wk of diet, and cyst growth was 34% lower after 3 wk (P < 0.0001). Kidney 18:2(n-6) levels were reduced in normal and diseased rats after as little as 1 wk of consuming the soy protein diet. Dietary soy protein also partially ameliorated the suppression of PGE₂ production observed in diseased kidneys. Compared with diseased kidneys from casein-fed rats, ex vivo PGE₂ release was 31–32% higher after 1 (P = 0.0281) and 3 (P = 0.0189) wk of dietary soy protein consumption. Hence, the first signs of a beneficial soy protein effect were observed after 1 wk of feeding, with further improvements evident after 3 wk. These data demonstrate that dietary soy protein compared with casein delays disease progression in an early stage of chronic kidney disease.

KEY WORDS: • dietary soy protein • chronic kidney disease • early intervention