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© 2004 The American Society for Nutritional Sciences J. Nutr. 134:655-660, March 2004

Nutritional Neurosciences

Dietary Fat Type Affects Vitamins C and E and Biomarkers of Oxidative Status in Peripheral and Brain Tissues of Golden Syrian Hamsters1

Concepción Sánchez-Moreno, Suzanne E. Dorfman*, Alice H. Lichtenstein* and Antonio Martín2

Nutrition and Neurocognition Laboratory and * Cardiovascular Nutrition Research Laboratory, Jean Mayer U.S. Department of Agriculture-Human Nutrition Research Center on Aging at Tufts University, Boston, MA

2To whom correspondence should be addressed. E-mail: antonio.martin{at}tufts.edu.

Oxidative stress is an important trigger in the complex chain of events leading to neurodegenerative diseases. On the other hand, dietary fatty acids play an essential role in brain function. The objectives of this study were to assess the effect of dietary fat type on vitamin C and vitamin E ({alpha}-and {gamma}-tocopherol) concentrations in peripheral and brain tissues and its effect on 8-epiPGF2{alpha} (F2-isoprostanes). Male Golden Syrian hamsters (n = 120, 8 wk old) were fed diets enriched in butter, hydrogenated fat (margarine), and canola and soybean oils. After 12 wk, hamsters were deprived of food, anesthetized with isoflurane, and killed via terminal exsanguination. Analyses of vitamins C, E, and 8-epiPGF2{alpha} were performed in peripheral tissues and brain. Hamsters consuming the margarine-enriched diet had lower (P < 0.05) vitamin C and {alpha}-tocopherol concentrations in liver, plasma, and brain, and higher (P < 0.02) plasma 8-epiPGF2{alpha} than groups fed the butter, and the canola and soybean oil diets. Liver and plasma {gamma}-tocopherol concentration was higher (P < 0.001) among the groups fed the soybean- and margarine-enriched diets compared with the other groups. {alpha}-Tocopherol was higher (P < 0.05) and 8-epiPGF2{alpha} lower (P < 0.01) among the groups fed the canola and soybean oil diets compared with the other groups. Across the groups, an inverse correlation between plasma levels of vitamin C and 8-epiPGF2{alpha} (r = -0.37, P = 0.03) and a positive correlation between plasma levels of vitamin C and {alpha}-tocopherol were observed (r = 0.341, P = 0.003). Hamsters fed the butter-enriched diet had a higher (P < 0.03) plasma uric acid concentration than the other groups. The results of this study provide new evidence concerning the effect of dietary fat on antioxidant status, which is important for the maintenance of good health.

KEY WORDS: • dietary fats • vitamin C • vitamin E • F2-isoprostanes • Golden Syrian hamsters






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